17049-50-2Relevant academic research and scientific papers
MODIFIED AMINE LIPIDS
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Page/Page column 193, (2020/07/04)
The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.
Olefin-assisted iron-catalyzed alkylation of aryl chlorides
Guelak, Samet,Gieshoff, Tim N.,Von Wangelin, Axel Jacobi
supporting information, p. 2197 - 2202 (2013/10/01)
A selective and operationally simple ironcatalyzed cross-coupling of aryl chlorides with alkylmagnesium halides has been developed. The reaction tolerates various functional groups and exhibits high chemoselectivity even in the presence of aryl bromides. Mechanistic studies indicate the essential role of the olefin substituent for substrate activation. Competing polymerization and reduction are effectively suppressed.
Method for producing alkyl-bridged ligand systems and transition metal compounds
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, (2008/06/13)
The invention relates to a method for producing highly substituted alkyl-bridged ligand systems on the basis of indene derivatives and transition metal compounds. Said alkyl-bridged ligand systems can be obtained in high yields using this method.
Substituted alkyl piperidines
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, (2008/06/13)
The present invention relates to a group of compounds which are novel substituted alkyl piperidines and which act to inhibit the synthesis of cholesterol in mammals and in fungi.
Novel substituted piperidines and their use as inhibitors of cholesterol synthesis
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, (2008/06/13)
The present invention relates to a group of compounds which are novel substituted piperidines and which act to inhibit the synthesis of cholesterol in mammals and in fungi.
IRON CATALYZED CROSS-COUPLING REACTIONS OF ACYL CHLORIDES WITH GRIGNARD REAGENTS. A MILD, GENERAL, AND CONVENIENT SYNTHESIS OF ALIPHATIC AND AROMATIC KETONES.
Fiandanese, V.,Marchese, G.,Martina, V.,Ronzini, L.
, p. 4805 - 4808 (2007/10/02)
Acyl chlorides couple with Grignard reagents at room temperature in the presence of catalytic amounts of tris(acetylacetonate)iron(III), Fe(acac)3.The reaction is general with respect to both reactants and provides a very mild and convenient method for the synthesis of aliphatic and aromatic ketones.
