1705-15-3Relevant academic research and scientific papers
Atom-efficient synthesis of 2,4,6-trisubstituted 1,3,5-triazinesviaFe-catalyzed cyclization of aldehydes with NH4I as the sole nitrogen source
Liu, Qiang,Ren, Shuang,Xiao, Jiang
, p. 22230 - 22233 (2020)
An atom-efficient, straightforward method for the synthesis of 2,4,6-triaryl-1,3,5-triazinesviairon-catalyzed cyclization of aldehydes with NH4I as the sole nitrogen source is demonstrated. This strategy works smoothly under air atmosphere, and affords symmetrical 2,4,6-trisubstituted and unsymmetrical 1,3,5-triazines with yields from 18% to 72%. Compared to other methods, the present protocol provides a straightforward and atom-efficient approach to 2,4,6-trisubstituted 1,3,5-triazines using an inexpensive, easily available ammonium salt as the sole nitrogen source. Research into the preliminary mechanism indicates thatN-benzylidenebenzimidamides are involved in this cyclization reaction.
Method for synthesizing 2, 4, 6-trisubstituted 1, 3, 5-triazine compound from aromatic aldehyde and ammonium iodide
-
Paragraph 0165-0168, (2020/08/06)
The invention discloses a method for synthesizing a 2, 4, 6-trisubstituted 1, 3, 5-triazine compound from aromatic aldehyde and ammonium iodide, and belongs to the field of organic synthesis. According to the method, aromatic aldehyde and ammonium iodide undergo a one-pot reaction under the catalytic action of a ferric salt, so that the 2, 4, 6-trisubstituted 1, 3, 5-triazine compound is obtained.According to the present invention, the small molecule aryl aldehyde raw material and the iron salt catalyst are used, such that the cost is low, the reaction conditions are mild, the symmetric 2, 4,6-trisubstituted 1, 3, 5-triazine compound can be highly selectively obtained, and the brand-new synthesis idea is provided for the triazine ring construction.
