170552-57-5Relevant academic research and scientific papers
2-Amino-3-oxohexahydroindolizinoindole-5-carboxylate Derivatives as New Scaffolds for Mimicking β-Turn Secondary Structures. Molecular Dynamics and Stereoselective Synthesis
Figuera, Natalia De la,Alkorta, Ibon,Garcia-Lopez, M. Teresa,Herranz, Rosario,Gonzalez-Muniz, Rosario
, p. 7841 - 7856 (2007/10/02)
Highly constrained 2-amino-3-oxohexahydroindolizinoindole-5-carboxylate derivatives of general formula 1 have been developed as novel β-turn mimetics.Molecular dynamics studies on model structures 2a and 2b have revealed that both indolizinoindole
2(S)-amino-3-oxo-11b(R)-hexahydroindolizino[8,7-b]indole-5(S)-carboxylate as a new type of β-turn dipeptide mimetic
De la Figuera,Rozas,Garcia-Lopez,Gonzalez-Muniz
, p. 613 - 614 (2007/10/02)
Molecular-modelling studies have shown that 2(S)-amino-3-oxo-11 b(R)-hexahydroindolizino[8,7-b]indole- 5(S)-carboxylate, stereoselectively prepared by Pictet-Spengler reaction between H-Trp-OMe and Z-Asp(H)-OBz and subsequent γ-lactamization, behaves as a
