170568-96-4Relevant academic research and scientific papers
Synthesis and evaluation of some quinoline Schiff bases as a corrosion inhibitor for mild steel in 1 N HCl
Mistry, Bhupendra M.,Jauhari, Smita
, p. 1049 - 1068 (2013)
N-((2-chloroquinolin-3-yl)methylene)aniline (CQM) and N-((2-chloroquinolin- 3-yl)methylene)-5-methylthiazol-2-amine (CQMA) were synthesized. The effect of CQM and CQMA have been investigated against mild steel (MS) in 1 N HCl solutions using conventional weight loss, potentiodynamic polarization, linear polarization, electrochemical impedance spectroscopy, UV-Vis spectroscopy and scanning electron microscopic studies. The losses in the weights of MS samples have proved that both CQM and CQMA are efficient inhibitors. The mixed mode of inhibition was confirmed by electrochemical polarizations. The adsorptions of these inhibitors are found to follow the Langmuir adsorption isotherm. CQM and CQMA adsorbs on the MS sample by chemisorptions.
Quinoline-based azetidinone and thiazolidinone analogues as antimicrobial and antituberculosis agents
Mistry, Bhupendra M.,Jauhari, Smita
, p. 647 - 658 (2013/04/10)
New azetidinone and thiazolidinone class of bioactive agents based on quinoline nucleus have been synthesized. 2-Chloroquinoline-3-carbaldehyde reacted with various substituted amine to form the corresponding Schiff base intermediates. We have derived final azetidinone and thiazolidinone analogues from Schiff bases using chloroacetyl chloride and 2-mercaptoacetic acid, respectively. The newly synthesized analogues were then examined for their antimicrobial activity against some bacterial and fungal strains as two gram -ve bacteria (Escherichia coli MTCC 739 and Pseudomonas aeruginosa MTCC 741), two gram +ve bacteria (Staphylococcus aureus MTCC 96 and Bacillus subtilis MTCC 430), two fungal species (Aspergillus niger MTCC 282 and Candida albicans MTCC 183) as well as against Mycobacterium tuberculosis strain H37Rv to develop a novel class of bioactive agents. The results of bioassay showed that some of the newly synthesized azetidinones and thiazolidinones emerged as lead molecules with excellent MIC (mg/mL) values against mentioned microorganisms compared to standard drugs. The structure of the final analogues has been confirmed on the basis of IR, 1H NMR, 13C NMR, and elemental analysis.
An efficient carbodiimide-mediated synthesis and dna-binding studies of novel 2-chloro/mercapto-quinoline-fused 1,3-thiazolidinones via one-pot three-component condensation
Lamani, Devappa S.,Reddy, K.R. Venugopala,Naik, H.S. Bhojya,Naik, H.R. Prakash,Naik
experimental part, p. 49 - 59 (2010/10/04)
A new and efficient method for the preparation of 2-(2-chloroquinolin-3-yl)-3-(4-methylphenyl)-1, 3-thiazolidin-4-one derivatives has been assembled by DCC:-mediated three-component one-pot reaction of amine, aldehyde, and mercaptoacetic acid. The final compounds were obtained in quantitative yields within 50 min. The synthesized compounds were characterized by elemental analysis, FT-IR, 1H-NMR, and mass spectral data. The selected compounds were studied for interaction with calf thymus DNA by electronic spectra, viscosity measurements as well as thermal denaturation studies. On binding to DNA, the absorption spectrum underwent bathochromic and hypochromic shifts. The binding constant (Kb) had a value of 5.3 × 105 M-1 for 2a and 5.8 × 105 M-1 for 3a. The viscosity measurements indicated that the viscosity of sonicated rod-like DNA fragments increased.
The behavior of 2-chloroquinoline-3-carboxaldehyde towards certain primary amines and activated methylenes
Ibrahim, Nabila M.,Yosef,Mahran
, p. 673 - 691 (2013/05/09)
THE REACTIVITY of 2-chloroquinoline-3-carboxaldehyde (1b). towards primary amines (2a-d, 3,4), hydrazines (5a-d, 6) and active methylene compounds (7,8) has been investigated. Assignments of the appropriate structures to the new reaction products have bee
Synthesis of some new 4-thiazolidinones as biologically potent agents
Datta, Neela J.,Khunt, Ranjan C.,Parikh
, p. 433 - 435 (2007/10/03)
Thiazolidin 3a-o, 4a-o have been synthesised by the cyclodensation of thioglycolic acid / thiolactic acid with N-aryl-2-chloroquinolin-3-yl-azomethine 2a-o which in turn have been prepared by the action of amines on 2-chloroquinolin-3-carboxaldehyde 1. The structure of the compounds 2a-o, 3a-o and 4a-o have been confirmed from elemental analyses, IR, IH NMR and mass spectral data. All the products have been screened for their antimicrobial activity against several microbes.
