17058-12-7Relevant articles and documents
Alkylation of Cycloalkanoindoles via Indolylmagnesium Salts: Synthesis of 3H-Indoles and Oxidative Rearrangement to Spiro-3'-ones
Rodriguez, Jose-Gonzalo,Andres, Angel San
, p. 1293 - 1299 (2007/10/02)
Alkylation of cycloalkanoindolylmagnesium iodide with alkyl halides has been analyzed to prepare cycloalkano-3H-indoles, methyl and N,N-dimethylpropyl derivatives.Spiro derivatives appear as secondary products in this reaction.Selectivity and optimization of the reaction has been determined and a mechanism for the formation of the spiro derivative is proposed.