170632-38-9Relevant academic research and scientific papers
1-(substituted benzyl)-3-(substituted aryl)-condensed pyrazole derivatives and processes of making the same
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, (2008/06/13)
The invention pertains to a process for preparing (1-substituted benzyl)-3-(hydroxy-carbonyl aryl) condensed pyrazoles or (1-substituted benzyl)-3-(hydroxymethyl aryl) condensed pyrazoles comprising the steps of: (a) reacting compound I and compound II, or compound III and compound IV, to produce compound V, which is a substituted aryl ketone, as follows: STR1 wherein Ar2 and At3 can be, independently, STR2 R1 is H, C1-3 alkyl, or X (halogen), R3 is H, C1-3 alkyl, X (halogen), or --OR radical, and R is H or C1-3 alkyl; the process comprising the following steps of: R2 represents CH2 OR, H, COOR, C1-3 alkyl, or X (halogen); (b) reacting the compound V with a hydrazine compound to form a hydrazone compound; (c) reacting the hydrazone compound compound with trifluoride etherate (BF3 ·Et2 O) to form a 1-(substituted benzyl) 3-(substituted aryl) condensed pyraxzole, which is represented by the following formula of STR3 Compound X can be further hydrolyzed or reduced to form corresponding carboxylic acids or alcohols.
1-Benzyl-3-(substituted aryl)-condensed pyrazole derivatives as inhibitors of platelet aggregation
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, (2008/06/13)
1-Benzyl-3-(substituted aryl) condensed pyrazoles of the general formula (A): wherein, R1 represents H, C1 3 alkyl, halogen, or -OR, in which R represents H or C1 3 alkyl; represents wherein R2/
