170641-06-2

Basic information

• Product Name: 1H-Tetrazole, 1-[(phenylmethoxy)methyl]-
• CAS NO: 170641-06-2
• Molecular Formula: C9H10N4O
• Molecular Weight: 190.205
• Mol File: 170641-06-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1H-Tetrazole, 1-[(phenylmethoxy)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Tetrazole, 1-[(phenylmethoxy)methyl]-(170641-06-2)
• EPA Substance Registry System: 1H-Tetrazole, 1-[(phenylmethoxy)methyl]-(170641-06-2)

Safety Data

• Hazardous Substances Data: 170641-06-2(Hazardous Substances Data)

Upstream product

• 288-94-8 1H-tetrazole 
• 3587-60-8 Benzyloxymethyl chloride 

Downstream Products

• 371143-40-7 1-benzyloxymethyl-5-(phenylacetylglycyl)tetrazole 
• 208122-80-9 (1-Benzyloxymethyl-1H-tetrazol-5-yl)-phenyl-methanol 

Relevant articles and documents

SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATIONS AND USES

The present invention relates to polysubstituted imidazolone derivatives, to the pharmaceutical compositions comprising them and to the therapeutic uses thereof in the human and animal health fields. The present invention also relates to a process for preparing these derivatives.

PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present application describes modulators of MIP-1 of formula (I) : or stereoisomers or pharmaceutically acceptable salts thereof, wherein m, Q, T, W, Z, R1, R3, R4, R5, R5a and R5b, are as set forth above. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using the modulators are disclosed.

Design, synthesis, and evaluation of α-ketoheterocycles as class C β-lactamase inhibitors

A series of specific α-ketoheterocycles (benzoxazole, thiazole, imidazole, tetrazole, and thiazole-4-carboxylate) has been synthesized in order to assess their potential as β-lactamase inhibitors. The syntheses were achieved either by construction of the heterocycle (benzoxazole) from an appropriate α-hydroxyimidate, followed by oxidation of the alcohol, or by direct reaction of methyl phenaceturate with a lithiated heterocycle. The properties of these compounds in aqueous solution are described and their inhibitory activity against β-lactamases assessed. They did inhibit the class C β-lactamase of Enterobacter cloacae P99 but not the TEM β-lactamase. The most effective inhibitor of the former enzyme (Ki = 0.11 mM) was 5-(phenylacetylglycyl) tetrazole, probably because it is an anion at neutral pH. Interpretation of the results was aided by computational models of the tetrahedral adducts. Most of the compounds also inhibited α-chymotrypsin but not porcine pancreatic elastase.