17072-38-7

Basic information

• Product Name: 4-ethyl-1H-pyrazole
• Synonyms: 4-ethyl-1H-pyrazole
• CAS NO: 17072-38-7
• Molecular Formula: C₅H₈N₂
• Molecular Weight: 96.13042
• Mol File: 17072-38-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 122 °C(Press: 16 Torr)
• Appearance: /
• Density: 0.9862 g/cm3
• PKA: 14.84±0.50(Predicted)
• CAS DataBase Reference: 4-ethyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethyl-1H-pyrazole(17072-38-7)
• EPA Substance Registry System: 4-ethyl-1H-pyrazole(17072-38-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 17072-38-7(Hazardous Substances Data)

Usage

Description

4-ethyl-1H-pyrazole is a pyrazole derivative with the molecular formula C5H8N2, known for its diverse biological activities and use as a building block in the synthesis of pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-ethyl-1H-pyrazole is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Research Applications:
4-ethyl-1H-pyrazole is used as a ligand in coordination chemistry and as a reagent in organic synthesis, aiding in the advancement of scientific research and the discovery of new compounds.
It is important to handle 4-ethyl-1H-pyrazole with caution due to its potential hazards if not properly managed, and it exhibits moderate solubility in water and relative stability under standard conditions.

Upstream product

• 900164-93-4 4-((trimethylsilyl)ethynyl)-1Η-pyrazole 
• 57121-49-0 4-ethynyl-1H-pyrazole 
• 85907-40-0 3-(dimethylamino)-2-ethyl-prop-2-enal 
• 342909-67-5 3-ethoxy-2-ethyl-prop-2-enal 

Downstream Products

• 1218920-81-0 C₂₉H₂₈ClN₇ 

Relevant articles and documents

19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROIDS AND METHODS OF USE THEREOF

Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I), and pharmaceutically acceptable salts thereof; wherein-, R1, R2, R3a, R3b, R4a, R4b, R5, R6, and R7are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.

PURINE DERIVATIVES AS A2A RECEPTOR AGONISTS

A compound of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof.and their preparation and use as A2A receptor agonists

Synthesis of the silver(I) complex of CH2[CH(pz 4Et)2]2 containing the unprecedented [Ag(NO3)4]3- anion: A general method for the preparation of 4-(alkyl)pyrazoles

A general two-step method for the syntheses of 4-(alkyl)pyrazoles has been developed. The first step involves the reaction between organyl diethylacetals and the Vilsmeier reagent to give a mixture of ethoxy-and dimethylamino- acroleins. This mixture reacts directly with hydrazine monohydrogenchloride to yield the desired (4-substituted)pyrazoles. The 4-(phenyl)pyrazole derivative exhibited a markedly lower solubility in common organic solvents. In the solid state structure the phenyl and pyrazolyl groups are nearly coplanar and extensive intermolecular CH-π interactions organize the molecules in two-dimensional sheets that are held in a three dimensional arrangement by NH...N hydrogen bonds. Tetrakis[(4-ethyl)pyrazolyl]propane, CH 2[CH(pz4Et)2]2, was prepared by a transamination reaction and reacts with Ag(NO3) to yield a compound with a 4:3 metal:ligand mole ratio that when crystallized by diffusion of Et2O into an acetone solution produced [Ag2{μ-CH 2[CH(pz4Et)2]2}2] 3[Ag(NO3)4]2 (1). This complex contains dimeric units in which two silver cations are sandwiched between two CH2[CH(pz4Et)]2 ligands and the counterion is the unprecedented tetra(nitrato)argentate anion. ESI mass spectral data support the existence of both the cationic dimeric units and the [Ag(NO 3)4]- anion in solution.