170727-02-3

Basic information

• Product Name: 3-Bromothiophene-2-sulphonyl chloride
• Synonyms: 3-BroMothiophene-2-sulfonyl chloride, 90+%;3-Bromo-2-(chlorosulphonyl)thiophene;3-bromo-2-thiophenesulfonyl chloride
• CAS NO: 170727-02-3
• Molecular Formula: C₄H₂BrClO₂S₂
• Molecular Weight: 261.55
• Mol File: 170727-02-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 39-41.5
• Boiling Point: 320.926 °C at 760 mmHg
• Flash Point: 147.891 °C
• Appearance: /
• Density: 1.985
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Bromothiophene-2-sulphonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromothiophene-2-sulphonyl chloride(170727-02-3)
• EPA Substance Registry System: 3-Bromothiophene-2-sulphonyl chloride(170727-02-3)

Safety Data

• Hazard Codes: C,T
• HazardClass: IRRITANT
• Hazardous Substances Data: 170727-02-3(Hazardous Substances Data)

Usage

General Description

3-Bromothiophene-2-sulphonyl chloride is a chemical compound with the molecular formula C4H2BrClO2S2. It is a white to off-white solid with a pungent odor that is primarily used as a reagent in the synthesis of pharmaceuticals and agrochemicals. It is a versatile building block in organic chemistry, and is commonly used as a sulfonylating agent for the introduction of the 2-thiophene-sulfonyl group into various organic compounds. Additionally, it can also be used as a reagent in the preparation of heterocyclic compounds, which are important in the pharmaceutical industry. 3-Bromothiophene-2-sulphonyl chloride is typically handled and stored under strict laboratory conditions due to its reactive and potentially hazardous nature.

InChI:InChI=1/C4H2BrClO2S2/c5-3-1-2-9-4(3)10(6,7)8/h1-2H

Upstream product

• 872-31-1 3-Bromothiophene 

Downstream Products

• 1304256-29-8 4-(3-bromo-thiophene-2-sulfonylamino)-2-hydroxy-benzoic acid 

Relevant articles and documents

An Invastigation of Structure and Conformation of Thiophene-2-sulphonyl Radicals

The e.s.r. spectra of a variety of photochemically generated thiophene-2-sulphonyl radicals are described.Their spin distribution is typical of ?-radicals; radicals without substituents at position 3 exhibit relatively rapid rotation about the C-S bond at all accessible temperatures while the 3-bromo-substituted ones demonstrate a marked conformational preference which has been interpreted in terms of a ?-type conjugated structure.These findings are substantiated also by the results of INDO calculations carried out for the unsubstituted thiophene-2-sulphonyl radical with different relative arrangements of the SO2 and heteroatomic moieties.

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

NOVEL DUAL ACTION RECEPTORS ANTAGONISTS (DARA) AT THE AT1 AND ETA RECEPTORS

The present invention relates to new compounds of the formula [Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, and R31 are as specified herein. The invention also relates to a method for preparation thereof, as well as combinations of the new compounds with previously known agents. The invention also relates to the use of the above-mentioned compounds and combinations for the preparation of a medicament for treating hypertension of different kinds, alleviating organ damage of different kinds, treating or preventing diabetic nephropathy, treating endothelin and angiotensin mediated disorders, and treating prostate cancer.