170750-35-3

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 14205-39-1 methyl (E)-3-aminocrotonate 
• 1026584-12-2 2-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid benzyl ester 

Downstream Products

• 170750-36-4 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl)-3,5-pyridinecarboxylic acid 3-methyl-5-benzylester 
• 170750-37-5 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluoprophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester 
• 1026945-82-3 4-(3,4-Dimethoxy-phenyl)-1-[3-(3-fluoro-phenoxy)-propyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-methyl ester 
• 125599-27-1 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl)-3,5-pyridinedicarboxylic acid 3-methylester 
• 170750-38-6 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluorophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methylester 
• 1028274-52-3 4-(3,4-Dimethoxy-phenyl)-1-[3-(3-fluoro-phenoxy)-propyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid monomethyl ester 

Relevant academic research and scientific papers

N-alkylated 1,4-dihydropyridines: New agents to overcome multidrug resistance

New N-alkylated 1,4-dihydropyridine derivatives were synthesized and their ability to overcome multidrug resistance was examined in vincristine-resistant P388 cells (P388/VCR cells). Compounds that possessed an arylalkyl substituent on the dihydropyridine ring nitrogen were more potent than verapamil in potentiating the cytotoxicity of vincristine against P388/VCR cells. However, neither drug effectively enhanced the antitumor activity of vincristine in tumor-bearing mice. Introduction of basic nitrogen-containing substituents on the side chain of 1,4-dihydropyridines gave improved activity in vitro and in vivo. The piperazine derivative 12c and 12o were more than 10 times as potent as verapamil in vitro. Four compounds selected for in vivo testing showed superior antitumor activity in P388/VCR-bearing mice in combination with vincristine. The structure-activity relationships of the compounds are discussed.

1,4-dihydropyridine compounds useful as reverse resistance agents

1,4-dihydropyridine derivatives of Formula 1 or pharmaceutically acceptable salts thereof: STR1 wherein the substituents are disclosed herein and which are useful against tumor cells which have acquired resistance to one or more drugs used as chemotherape