170799-31-2Relevant academic research and scientific papers
Substituted morpholinyl compounds
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Page/Page column 11, (2008/12/04)
This disclosure relates to novel substituted morpholinyl compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of
Synthesis and biological activities of metabolites of mosapride, a new gastroprokinetic agent
Kato,Morie,Yoshida
, p. 699 - 702 (2007/10/02)
In order to confirm the proposed structures of two metabolites 3 and 4 of the gastroprokinetic agent mosapride [4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)-2 -morpholinyl]methyl}benzamide, 2], the compounds were synthesized and their biological activity was examined. The structures of the metabolites were confirmed by means of comparison with the synthetic compounds. The serotonin 5-HT4 receptor agonistic activities of the metabolites were found to be less than that of mosapride.
