1708-19-6Relevant academic research and scientific papers
Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids
Allwood, Daniel M.,Blakemore, David C.,Brown, Alan D.,Ley, Steven V.
, p. 328 - 338 (2014/01/17)
The coupling of aromatic moieties with saturated heterocyclic partners is currently an area of significant interest for the pharmaceutical industry. Herein, we present a procedure for the metal-free coupling of 4-, 5-, and 6-membered saturated heterocyclic p-methoxyphenyl (PMP) sulfonylhydrazones with aryl and heteroaromatic boronic acids. This procedure enables a simple, two-step synthesis of a range of functionalized sp2-sp3 linked bicyclic building blocks, including oxetanes, piperidines, and azetidines, from their parent ketones.
