17083-23-7

Basic information

• Product Name: H-TYR(TBU)-OTBU HCL
• Synonyms: O-TERT-BUTYL-L-TYROSINE TERT-BUTYL ESTER HYDROCHLORIDE;O-T-BUTYL-L-TYROSINE T-BUTYL ESTER HYDROCHLORIDE;TYROSINE(TBU)-OTBU HCL;H-TYR(TBU)-OTBU HCL;H-Tyr(tBu)-OBut HCl;Tyr(tBu)-OtBu.HCl;TYR(TBU)-OTBU·HCL 98+%;TYR(BZL)-OBZLHCL
• CAS NO: 17083-23-7
• Molecular Formula: C₁₇H₂₇NO₃*ClH
• Molecular Weight: 329.86
• Product Categories: Amino hydrochloride;A - H;Amino Acids;Modified Amino Acids
• Mol File: 17083-23-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 159-160℃
• Boiling Point: 408.6 °C at 760 mmHg
• Flash Point: 200.9 °C
• Appearance: /
• Density: 1.026g/cm3
• Vapor Pressure: 6.01E-06mmHg at 25°C
• Refractive Index: 1.504
• Storage Temp.: −20°C
• CAS DataBase Reference: H-TYR(TBU)-OTBU HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-TYR(TBU)-OTBU HCL(17083-23-7)
• EPA Substance Registry System: H-TYR(TBU)-OTBU HCL(17083-23-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 17083-23-7(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

InChI:InChI=1/C17H27NO3/c1-16(2,3)20-13-9-7-12(8-10-13)11-14(18)15(19)21-17(4,5)6/h7-10,14H,11,18H2,1-6H3/t14-/m0/s1

Upstream product

• 4089-07-0 L-tyrosine ethyl ester monohydrochloride 
• 16679-94-0 N-[(phenylmethoxy)carbonyl]-L-tyrosine 
• 1164-16-5 Z-L-Tyr-OH 
• 17083-17-9 O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-L-tyrosine 1,1-dimethylethyl ester 

Downstream Products

• 217453-70-8 2-{[1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-3-[4-(1H-tetrazol-5-ylmethoxy)-phenyl]-propionic acid tert-butyl ester 
• 217453-69-5 (S)-3-(4-Cyanomethoxy-phenyl)-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-propionic acid tert-butyl ester 
• 217453-68-4 (S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester 
• 217453-67-3 (S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-3-(4-hydroxy-phenyl)-propionic acid tert-butyl ester 
• 907189-07-5 tert-butyl (S)-3-(4-tert-butyloxyphenyl)-2-((S)-2-((2S,4S)-2-tert-butyl-4-tert-butyloxycarbonylmethyl-5-oxo-1,3-dioxolan-4-yl)-but-3-enoylamino)-propanoate 

Relevant articles and documents

Conventional Synthesis of Thymopoietin 32-36 (TP 5) Using the 1-(1-Adamantyl)-1-methyletoxycarbonyl Group

A synthesis of high yields of TP 5 is described.The α-amino functions were blocked by the acid-labile 1-(1-adamantyl)-1-methylethoxycarbonyl-(Adpoc)group.The Adpoc group is cleaved under mild acidolytic conditions with 3percent TFA in CH2Cl2 while the tert-butyl residues remained intact.This selective cleavage of the Adpoc group compared with the Boc and tert-butyl residues allows new strategies for the synthesis of large peptides. - Keywords: Adpoc, Amino acids, Thymopoietin