170848-10-9Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS
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, (2008/06/13)
Compounds of the formula I, STR1 are NMDA antagonists and useful in the treatment and prevention of nervous system related pathological conditions resulting from overstimulation by excitatory amino acids. Methods for their preparation and pharmaceutical c
New heteroaryl-spaced phosphono α-amino acids are competitive NMDA antagonists with analgesic activity
Swahn, Britt-Marie,Claesson, Alf,Pelcman, Benjamin,Besidski, Yevgeni,Molin, Hakan,Sandberg, Mats P.,Berge, Odd-Geir
, p. 1635 - 1640 (2007/10/03)
The synthesis and the NMDA receptor binding affinities of α-amino-3-(phosphonomethyl)-2-naphthalenepropanoic acid, α-amino-3-(phosphonomethyl)-2-benzofuranpropanoic acid, a series of substituted (R)-α-amino-3-(phosphonomethyl)-2-quinolinepropanoic acids, (R)-α-amino-3-(phosphonomethyl)-1,8-naphthyridine-2-propanoic acid and (R)-α-amino-3-(phosphonomethyl)-1,6-naphthyridine-2-propanoic acid are reported.
