170856-87-8

Upstream product

• 63-74-1 sulfanilamide 
• 110-85-0 piperazine 
• 402-46-0 4-fluorophenylsulphonamide 
• 824-75-9 p-fluorobenzamide 

Downstream Products

• 946156-94-1 C₂₆H₃₄N₄O₄S 
• 170858-07-8 (S)-(-)-3-Bromo-4-[4-[2-(6-bromoisochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide 
• 170858-29-4 (RS)-4-[4-[(Isochroman-1-yl)methyl]piperazin-1-yl]benzenesulfonamide 
• 170858-33-0 sonepiprazole 

Relevant academic research and scientific papers

BCL-2 INHIBITORS AND THEIR USE AS PHARMACEUTICALS

The disclosure is directed to, in part, to BCL-2 inhibitors, pharmaceutical compositions comprising the same, as well as methods of their use and preparation.

Novel protein inhibitor and preparation method and application thereof

The invention provides a novel protein inhibitor and a preparation method and application thereof, and specifically provides a compound as shown in a formula I, wherein definitions of all groups are described in the specification. The compound has good Bcl-2 family protein inhibition activity and can be used for preparing a series of medicines for treating diseases related to Bcl-2 family proteinactivity.

ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS

Compounds represented by Formula (I) and (II) and salts thereof are described herein. The compounds or salts of Formula (I) and (II) may be used to treat senescence-associated diseases and disorders.

Organocatalytic, Enantioselective Synthesis of 1- and 3-Substituted Isochromans via Intramolecular Oxa-Michael Reaction of Alkoxyboronate: Synthesis of (+)-Sonepiprazole

The enantioselective oxa-Michael reaction of alkoxyboronate strategy was demonstrated to provide a new and practical route to enantioriched 1- and 3-substituted isochromans using a chiral bifunctional organocatalyst. Furthermore, this methodology was exte

G-PROTEIN COUPLED RECEPTOR AGONISTS

Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

External chiral ligand-induced enantioselective lithiation/S(E)2 reactions of isochroman and phthalan

Treatment of isochroman and phthalan with a t-BuLi/chiral bis(oxazoline) complex followed by reaction with carbon-electrophiles such as benzaldehyde and CO2 is shown to afford the α-substituted derivatives in moderate-to-high enantioselectivities (up to 97% ee and 83% ee, respectively). The asymmetric induction is proved to occur at the post-lithiation step. (C) 2000 Elsevier Science Ltd.

Heterocyclic compounds for the treatment of CNS and cardiovascular disorders

Novel aromatic bicyclic amines of formula (I) STR1 are useful in treating central nervous system disorders and cardiac arrhythmias and cardiac fibrillation.

IMIDAZO[1,2-A]PYRIDINES FOR THE TREATMENT OF CNS AND CARDIAC DISEASES

The present invention relates to imidazo[1,2-a]pyridine compounds of formula (1) STR1 which are dopamine D-4 antagonists and useful as anti-psychotic agents.