170891-76-6

Basic information

• Product Name: α,α,α-trimethyl-N-(quinolin-8-yl)acetamide
• Synonyms: α,α,α-trimethyl-N-(quinolin-8-yl)acetamide
• CAS NO: 170891-76-6
• Molecular Weight: 228.294
• Mol File: 170891-76-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: α,α,α-trimethyl-N-(quinolin-8-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: α,α,α-trimethyl-N-(quinolin-8-yl)acetamide(170891-76-6)
• EPA Substance Registry System: α,α,α-trimethyl-N-(quinolin-8-yl)acetamide(170891-76-6)

Safety Data

• Hazardous Substances Data: 170891-76-6(Hazardous Substances Data)

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 1217798-05-4 C₁₆H₁₇N₃OPd 
• 624-31-7 4-tolyl iodide 

Downstream Products

• 1616877-80-5 (E)-N-(5-cinnamylquinolin-8-yl)pivalamide 
• 1628847-26-6 C₁₈H₁₆N₂ 
• 1616877-84-9 (E)-N-(5-(3-p-tolylallyl)quinolin-8-yl)pivalamide 
• 1616877-85-0 (E)-N-(5-(3-(4-fluorophenyl)allyl)quinolin-8-yl)pivalamide 
• 1616877-86-1 (E)-N-(5-(3-(4-chlorophenyl)allyl)quinolin-8-yl)pivalamide 
• 1616877-87-2 (E)-N-(5-(3-(4-bromophenyl)allyl)quinolin-8-yl)pivalamide 
• 1616877-88-3 (E)-N-(5-(3-(3-(trifluoromethyl)phenyl)allyl)quinolin-8-yl)pivalamide 
• 1616877-89-4 (E)-N-(5-(2-methyl-3-phenylallyl)quinolin-8-yl)pivalamide 
• 1616877-90-7 (E)-N-(5-(2-benzylideneheptyl)quinolin-8-yl)pivalamide 
• 1616877-91-8 (E)-N-(5-(2-chloro-3-phenylallyl)quinolin-8-yl)pivalamide 
• 1215018-73-7 2,2-dimethyl-N-(quinolin-8-yl)-3-(p-tolyl)propanamide 

Relevant articles and documents

Pd(II)-catalyzed intermolecular arylation of unactivated C(sp 3)-H bonds with aryl bromides enabled by 8-aminoquinoline auxiliary

An example of using readily available, less reactive aryl bromides as arylating reagents in the Pd(II)-catalyzed intermolecular arylation of unactivated C(sp3)-H bonds is described. This reaction was promoted by a crucial 8-aminoquinolinyl directing group and a K2CO3 base, enabling regiospecific installation of an aryl scaffold at the β-position of carboxamides. A mechanistic study by DFT calculations reveals a C(sp3)-H activation-led pathway featuring the oxidative addition as the highest energy transition state.