170894-66-3Relevant academic research and scientific papers
Thionation of ω-hydroxy amides with Lawesson's reagent: Synthesis of thioenamides and sulfur-containing heterocycles
Nishio, Takehiko,Sekiguchi, Hiroshi
, p. 5017 - 5026 (2007/10/03)
The thionation of ω-hydroxy amides with Lawesson's reagent [LR: 2,4- bis(p-methoxyphenyl)-1,3,2,4-dithiaphosphetane-2,4-disulfide] is described. The treatment of 3-hydroxy amides 1 with LR exclusively gave thioenamides 2 in fair yields. The treatment of 4-hydroxy amides 5 with LR yielded sulfur- containing heterocycles such as tetrahydrothiophene-2-imines 6 and tetrahydrothiophene-2-thione 7a through cyclization of intermediates, 4- mercapto amides 8. The 5-hydroxy amides 13 also reacted with LR to afford tetrahydrothiopyrane-2-thione 14 as the the sole product.
Sulfur-containing heterocycles derived by the reaction of hydroxy-amides and Lawesson's reagent
Nishio, Takehiko
, p. 6113 - 6116 (2007/10/02)
A simple one-pot reaction between hydroxy-amides (1), located 1,3- or 1,4- to each other, and Lawesson's reagent (LR) gives sulfur-containing heterocycles such as tetrahydrothiophene-2-imines (4), tetrahydrothiophene-2-thione (5) and tetrahydrothiopyran-2
