170901-07-2

Upstream product

• 21800-83-9 13β-ethyl-gon-4-en-3,17-dione 
• 2322-77-2 13β-ethyl-3-methoxygona-2,5(10)-diene-17-one 
• 20799-05-7 DL-13β-ethyl-gona-4,9-diene-3,17-dione 
• 19882-75-8 13-Ethyl-3-methoxygona-1,3,5⁽¹⁰⁾,9⁽¹¹⁾-tetraen-17-one 
• 141300-07-4 (8S,11S,13S,14S)-13-Ethyl-11-hydroperoxy-1,6,7,8,11,12,13,14,15,16-decahydro-2H-cyclopenta[a]phenanthrene-3,17-dione 
• 140221-18-7 (8S,13S,14S)-13-Ethyl-1,4,6,7,8,12,13,14,15,16-decahydro-2H-cyclopenta[a]phenanthrene-3,17-dione 
• 4222-96-2 DL-13β-ethyl-gon-5(10)-ene-3,17-dione 
• 24957-65-1 DL-13β-ethyl-11β-hydroxy-gona-4,9-dien-3,17-dione 

Downstream Products

• 54048-10-1 etonogestrel 
• 54024-22-5 desogestrel 
• 1574323-08-2 C₂₂H₃₂O₃ 
• 1574323-07-1 C₂₁H₃₀O₄ 

Relevant academic research and scientific papers

A novel and efficient process to 13β-ethyl-gon-4-ene-3,11,17-trione

A novel synthetic process to 13β-ethyl-gon-4-ene-3,11,17-trione with the total yield of 44% starting from 13β-ethyl-17β-hydroxy-3-methoxy-gona-2,5(10)-diene was described.

Intermediate for synthesis of desogestrel and preparation method thereof

The invention relates to a steroid compound and application of the same to preparation of a desogestrel intermediate, i.e., 13-ethylsterane-3,11,17-trione. The novel compound is prepared through oxidation, transposition, hydroboration-oxidation, ketalization and a lithium-ammonia reaction of starting materials; and then 13-ethylsterane-3,11,17-trione is prepared by using the compound, and the preparation process is simple, easily practicable, environment-friendly, high in yield, and suitable for industrial production.

PROCESS FOR THE SELECTIVE ISOLATION, PURIFICATION AND SEPARATION OF MONOHYDROXYLATED 3,17-DIKETO-STEROID COMPOUNDS

The subject of the present invention is a new process for the selective isolation, purification and separation of monohydroxylated 3,17-diketo-steroid compounds from a solution obtained preferably by microbiological way containing a mixture of steroid compounds via selective extraction, purification and selective crystallization of the steroid compounds by treatment of several solvents.

PROCESS AND NEW INTERMEDIATES FOR THE PREPARATION OF STEROIDS WITH A PROGESTOGEN ACTIVITY

The present invention relates to a new process of synthesis and to some new intermediates for the preparation of steroids with progestogen activity, more particularly, for the preparation of Desogestrel of formula (I). Said process is characterized by the regioselective reduction of the compound of formula (II) to give the intermediate of formula (III).