170902-81-5 Usage
Uses
Used in Pharmaceutical Industry:
Aprepitant is used as a selective neurokinin-1 (NK-1) receptor antagonist for the treatment of various conditions. Its primary application is in the management of chemotherapy-induced nausea and vomiting (CINV) by blocking the action of substance P, a neurotransmitter involved in the vomiting reflex. This makes Aprepitant a valuable asset in improving the quality of life for patients undergoing chemotherapy.
Additionally, Aprepitant's mechanism of action as an NK-1 receptor antagonist suggests potential applications in other areas, such as the treatment of migraines and anxiety disorders. Further research and clinical trials are necessary to explore these possibilities and establish Aprepitant's efficacy in these contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 170902-81-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,9,0 and 2 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 170902-81:
(8*1)+(7*7)+(6*0)+(5*9)+(4*0)+(3*2)+(2*8)+(1*1)=125
125 % 10 = 5
So 170902-81-5 is a valid CAS Registry Number.
170902-81-5Relevant academic research and scientific papers
Synthesis of all enantiomerically pure diastereomers of aprepitant
Gangula, Srinivas,Elati, Chandrashekhar R.,Mudunuru, Satish Varma,Nardela, Anitha,Dongamanti, Ashok,Bhattacharya, Apurba,Bandichhor, Rakeshwar
experimental part, p. 2254 - 2268 (2010/09/11)
Syntheses of all eight enantiomerically pure diastereomers of aprepitant and assignment of absolute configuration at newly generated stereocenters by NMR and X-ray crystallographic analysis were achieved. Copyrigh
