170912-81-9

Upstream product

• 394248-99-8 4-(2-methoxy-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester 
• 62845-42-5 1-acetyl-4-(2-methoxyphenyl)piperazine 

Downstream Products

• 1395030-33-7 4-(4-(oxetan-3-yl)piperazin-1-yl)benzenamine 
• 1433823-88-1 1-(4-nitrophenyl)-4-(oxetan-3-yl)piperazine 
• 1362020-51-6 (4-(2-methoxy-4-nitrophenyl)piperazin-1-yl)(1-(2-methoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone 
• 178993-16-3 1,3,5-Trimethyl-6-[[3-[4-(2-methoxy-4-nitrophenyl)-1-piperazinyl]propyl]amino]-2,4(1H,3H)-pyrimidinedione 
• 433214-09-6 1-(4-amino-2-methoxyphenyl)piperazine 
• 394249-01-5 4-[4-(4-cyclohexyl-benzoylamino)-2-methoxy-phenyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 394249-00-4 4-(4-amino-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester 
• 394248-99-8 4-(2-methoxy-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester 
• 835633-78-8 4-(4-isopropylpiperazin-1-yl)-3-methoxyaniline 
• 178993-25-4 1,3,5-Trimethyl-6-[[3-[4-(4-amino-2-methoxyphenyl)-1-piperazinyl]propyl]amino]-2,4(1H,3H)-pyrimidinedione 

Relevant academic research and scientific papers

COMPOUNDS AND THEIR USES AS SPLEEN TYROSINE KINASE INHIBITORS

Provided are compounds of Formula (I) which can be used as Syk inhibitors and potently as therapeutic agents against diseases mediated by Syk.

IMIDAZOPYRAZINE SYK INHIBITORS

Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suf-fering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of an imidazopyrazine compound effective to reduce signs or symptoms of the disease or dis-order are provided.

Uracil derivatives

Compounds of formula I, in which the substituents and symbols have the meanings indicated in the description, R5-HT1A-agonists and alpha 1-adrenoceptor blockers. Compositions containing these compounds as active ingredients are useful for treating those d