170916-55-9 Usage
Uses
Used in Pharmaceutical Industry:
1-(4-[(3,4-DICHLOROBENZYL)OXY]PHENYL)ETHAN-1-ONE is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Fragrance Industry:
1-(4-[(3,4-DICHLOROBENZYL)OXY]PHENYL)ETHAN-1-ONE is used as a fragrance ingredient. Its distinct aromatic properties make it a valuable component in the creation of perfumes and other scented products, enhancing the sensory experience for consumers.
Used in Flavoring Industry:
1-(4-[(3,4-DICHLOROBENZYL)OXY]PHENYL)ETHAN-1-ONE is used as a flavoring agent. Its taste-enhancing properties are utilized in the food and beverage industry to create a variety of flavors, improving the overall taste and appeal of products.
Used in Chemical Synthesis:
1-(4-[(3,4-DICHLOROBENZYL)OXY]PHENYL)ETHAN-1-ONE is used as a precursor in the synthesis of various organic compounds. Its versatile chemical structure makes it a valuable starting material for the production of a wide range of chemical products, further expanding its applications in the field of chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 170916-55-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,9,1 and 6 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 170916-55:
(8*1)+(7*7)+(6*0)+(5*9)+(4*1)+(3*6)+(2*5)+(1*5)=139
139 % 10 = 9
So 170916-55-9 is a valid CAS Registry Number.
InChI:InChI=1/C15H12Cl2O2/c1-10(18)12-3-5-13(6-4-12)19-9-11-2-7-14(16)15(17)8-11/h2-8H,9H2,1H3
170916-55-9Relevant articles and documents
Continuous Flow Conditions for High Temperature Formation of a Benzodioxan Pharmaceutical Intermediate: Rapid Scaleup for Early Phase Material Delivery
Buser, Jonas Y.,Huang, Ping,Li, Pengbin,Li, Zhongbo,Miguel Minguez, Jose,Ryan, Sarah J.,Sun, Baoquan,Yang, Shaohui,Zhu, Ruiheng
, p. 1938 - 1947 (2020)
We have developed a continuous flow method to enable rapid scaleup of an enantioenriched benzodioxan intermediate. We propose that the reaction proceeds through an intramolecular SNAr cyclization. Interestingly, traditional SNAr conditions resulted in impurity formation. When the starting material 2 was treated with alkali base in polar aprotic solvents, an undesired product regioisomer was observed. The formation of this regioisomer impurity could be suppressed by using a less polar solvent, an organic base, and high temperature. By employing continuous flow technology, these high temperature conditions could be scaled up to produce 540 g of the desired intermediate. The continuous flow reactor allowed for rapid thermal equilibration, which minimized problematic product decomposition by reducing the time that the product was exposed to high temperature.
