170917-22-3

Upstream product

• 108-86-1 bromobenzene 
• 170917-21-2 2-phenylthio-7-methoxycarbonyl-7-azabicyclo [2,2,1] hept-2-ene 

Relevant academic research and scientific papers

2-Phenyl-7-azabicycloheptanes and 6-phenyl-8-azabicyclo

The invention relates to a group of novel 2-phenyl-7-azabicyclo [2,2,1] heptane and 6-phenyl-8-azabicyclo [3,2,1] octane derivatives having central nervous system, in particular analgesic activity, and to a method for the preparation of these compounds. The compounds have the general formula (1) wherein R is hydrogen or alkyl (1-3C), R1 is alkyl (1-3C), alkoxy (1-3C), halogen, hydroxy or esterified hydroxy, amino or acetylated amino, or methylenedioxy, n has the value 0-3, and p is 1 or 2.

Synthesis of endo-2-phenyl-7-azabicyclo[2.2.1]heptane via high pressure Diels-Alder reactions of pyrroles

A straightforward route to racemic endo-2-phenyl-7-azabicyclo[2.2.1]heptane (an analogue of epibatidine) is described via the high pressure Diels-Alder reaction of 1-methoxycarbonyl-3-phenylthio-pyrrole with phenyl vinyl sulphone.