170930-45-7Relevant academic research and scientific papers
A highly selective H/D exchange reaction of 1,4-dihydropyridines
Wang, Kaiqian,Chen, Xiaoping,Peng, Xiao,Wang, Ping,Liang, Feng
, p. 3845 - 3852 (2019)
Herein, we report a simple, economical, and effective acid-mediated method for the in situ deuteration of Hantzsch esters and their 4-substituted derivatives, including some drugs that constitute important calcium channel blockers which are effective for
Method of using deuterated calcium channel blockers
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Page column 4-5, (2010/02/04)
A method of enhancing the efficiency and increasing the duration of action of drugs (e.g. dihydropyridines and anti-bacterials) and particularly of nifedipine and penicillins wherein one or more hydrogen atoms are deuterated and wherein the deuterated drug has unexpectedly improved properties when used in much lower concentrations than unmodified drug. A method for determining the identity and bioequivalency of a new drug is also disclosed wherein the molecular and isotope structure of a new drug is determined by isotope ratio mass spectrometry and compared with the molecular and isotope structure of a known human drug.
