170936-98-8Relevant academic research and scientific papers
Synthesis of Potential Antimetabolites in the Series of Carbon-modified Pyrimidine 2'-Deoxynucleosides
Bakhmedova, A. A.,Yartseva, I. V.,Mel'nik, S. Ya.
, p. 38 - 41 (2007/10/02)
Diastereomeric 2',3'-dideoxy-3'-(N'-ethylsuccinimido)- or 2',5'-dideoxy-5'-(N'-ethylsuccinimido)aminonucleosides were prepared through the interaction of 3'-amino-2',3'-dideoxy- or 5'-amino-2',5'-dideoxy-5-substituted pyrimidine nucleosides with N-ethylmaleimide in DMF in the presence of triethylamine.In the case of 5-trimethylsilyl- and 5-benzyloxymethyl-2'-deoxyuridine, diastereomeric 3'-(N'-ethylsuccinimido)amino derivatives were separated by preparative TLC.The structures of the compounds synthesized were confirmed by the UV, IR and 1H NMR spectra.The prepared modified nucleosides are not cytotoxic in vitro in the CaOv cell culture. Key words: nucleosides, 3'- and 5'-modified; N-ethylmaleimide, diastereomers, cytotoxic properties.
