170948-50-2Relevant academic research and scientific papers
Utilisation of 6-amino-2,3-dimethylquinoxaline for the synthesis of tricyclic pyridoquinoxalines via Gould-Jacobs reaction
Salon, Jozef,Milata, Viktor,Pronayova, Nadezda,Lesko, Jan
, p. 1691 - 1697 (2007/10/03)
Treatment of 2,3-dimethylquinoxalin-6-amine with (alkoxymethylidene)malonic derivatives gave the corresponding (quinoxalylamino)ethenes, which on heating cyclized to angularly annelated pyrido[3,2-f]quinoxalin-10-ones.
Synthesis and antimalarial activity of pyridoquinoxalines and their N-oxides
Venugopalan, B.,Souza, E. Pinto de,Sathe, K. M.,Chatterjee, D. K.,Iyer, N.
, p. 778 - 790 (2007/10/03)
Unsubstituted, 2,3-dimethyl, and 2,3-diphenyl 10-chloro pyridoquinoxalines have been prepared and converted to 10-substituted amino and Mannich base derivatives.Pyridoquinoxaline undergoes oxidation in the presence of m-CPBA to give the corresponding mono and bis N-oxides.The mono N-oxide reacts with POCl3 to give the dichloro derivative and with trimethyl silyl cyanide to give the 8-cyano-10-chloro derivative.The dichloro pyridoquinoxaline further undergoes oxidation with m-CPBA to give dichloro mono N-oxide.All the compounds have beeen testedin the Plasmodium berghei infected mice by oral route.Compounds 9, and 12 displayed 100percent activity in K-173 infected mice at 25 mg/kg.
