170956-70-4Relevant academic research and scientific papers
Lithium derivatives from enatiomerically pure 2-(2'-haloethyl) dioxolanes: Formation and use as chiral propanol homoenolate synthons
Garcia-Valverde,Pedrosa,Vicente
, p. 1787 - 1794 (1995)
Condensation of acetals of 3-chloro- and 3-bromopropanal with (-)-1,4-di-O-benzyl-L-threitol and (-)-cis-2,3-bornanediol leads to the corresponding 2-(2'-chloroethyl-)- and 2-(2'-bromoethyl)dioxolanes that were converted into the Li-derivatives by transhalometallation with t-butyllithium in excellent yields. These chiral propanol homoenolates react with benzaldehyde and acetophenone yielding carbinols in moderate chemical yields and low diastereomeric excesses.
