170963-76-5Relevant academic research and scientific papers
Antitumor and immunosuppressive activity of Merbarone's analogues and arylidenehydrazinopyrimidines
Dlugosz,Machon
, p. 529 - 534 (2007/10/02)
The synthesis of Merbarone's analogues, the 4-thio- or 4-oxo derivatives of 5-carbamoyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine is described, starting from 5-carboxy-6-methyl-2-oxo-4-thioxo-1,2,3,4-tetrahydropyrimidine. That was also used as starting material for synthesis of NCS624947 analogues, the 4-arylidenehydrazino-5-carbamoylpyrimidines. The reduction of arylidenehydrazinopyrimidines with hydrogen on Pd/C was also performed. The obtained compounds were successfully tested for anticancer and immunomodulating activity.
