17099-07-9

Usage

Uses

Used in Textile Industry:
p-Chloro-N-(o-chlorobenzylidene)aniline is used as a dye intermediate for the production of azo dyes. These dyes are extensively used in the textile industry to provide a wide range of colors and shades to fabrics.
Used in Pharmaceutical Industry:
Due to its antimicrobial properties, p-Chloro-N-(o-chlorobenzylidene)aniline has potential applications in the field of medicine. It can be used as an antibacterial and antifungal agent to combat various infections.
Used in Chemical Industry:
As a chemical compound, p-Chloro-N-(o-chlorobenzylidene)aniline can also be used in the chemical industry for the synthesis of other compounds and materials.

InChI:InChI=1/C13H9Cl2N/c14-11-5-7-12(8-6-11)16-9-10-3-1-2-4-13(10)15/h1-9H/b16-9+

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 106-47-8 4-chloro-aniline 
• 823-86-9 N-(4-chlorophenyl)hydroxylamine 
• 878561-50-3 C-(2-chlorophenyl)-N-(4-chlorophenyl)nitrone 

Downstream Products

• 102912-63-0 2-(2-chloro-styryl)-naphtho[1,2-d]thiazole 
• 107624-75-9 N-(o-chlorobenzyl)-p-chloroaniline 
• 927194-63-6 ethyl 5-(2-chlorophenyl)-1-(4-chlorophenyl)-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-4-carboxylate 

Relevant academic research and scientific papers

Development of novel vitamin D receptor-coactivator inhibitors

Nuclear receptor coregulators are master regulators of transcription and selectively interact with the vitamin D receptor (VDR) to modulate cell differentiation, cell proliferation, and calcium homeostasis. Herein, we report the syntheses and evaluation of highly potent and selective VDR-coactivator inhibitors based on a recently identified 3-indolylmethanamine scaffold. The most active compound, PS121912, selectively inhibited VDR-mediated transcription among eight other nuclear receptors tested. PS121912 is also selectively disrupting the binding between VDR and the third nuclear receptor interaction domain of the coactivator SRC2. Genetic studies revealed that PS121912 behaves like a VDR antagonist by repressing 1,25-(OH)2D3 activated gene transcription. In addition, PS121912 induced apoptosis in HL-60.

Synthesis of 4-imino-2H,3H,5H-[1,2,5]thiadiazolidin-1-oxide through cycloaddition reaction of N-sulphinylanilines and N-(α-cyano-α-aryl) -methylanilines

Through the normal mode of cycloaddition reaction of N-(α-cyano- α-aryl)-methylanilines (II) onto N-sulphinylanilines (III) has provided 2,3,5-triaryl-4-imino-2H,3H,5H-[1,2,5]thiadiazolidin-1-oxides (IV). The present protocol has advantage of convenient operation to synthesize heterocyclics in good yield.

CANNABINOID RECEPTOR LIGANDS AND USES THEREOF

Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein.

Synthesis and reduction of nitrones of 2-chlorobenzaldehyde and their antifungal potential

Condensation of 2-chlorobenzaldehyde with phenylhydroxylamines resulted in the foripation of C-(2-chlorophenyl)-N-phenylnitrones (1a-6a) which were characterized on the basis of elemental analysis and spectral studies. Sodium borohydride reduction of the nitrones was carried out and the nitrones were screened for their antifungal potential against five phytopathogenic fungi.

Polarographic investigations on azomethines: Benzal-p-chloranilines in alkaline medium and effect of substituents on half-wave potentials

Polarographic behavior of twenty-four substituted benzal-p-chloranilines has been investigated in 50percent methanol-water medium in alkaline pH range.The experimental conditions for the study were so designed that no appreciable hydrolysis of the Schiff