171002-23-6Relevant academic research and scientific papers
Biocatalytic approach to enatiomerically pure β-amino acids
Soloshonok,Fokina,Rybakova,Shishkina,Galushko,Sorochinsky,Kukhar,Savchenko,Svedas
, p. 1601 - 1610 (2007/10/02)
β-Aryl-β-amino acids were prepared in good chemical yield and high enantiomeric purity (> 95% ee) via penicillin acylase-catalyzed hydrolysis of the corresponding N-phenylacetyl derivatives. The (R)-enantiomers were the fast-reacting isomers in all cases studied. The biocatalytic procedure described employs a very simple set of reactions using inexpensive commercially available chemicals and enzyme, and could be easily scaled up.
