171002-98-5

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 502699-56-1 (2S,2'S)-<(1R,2R)-1,2-dibenzyloxy-ethan-diyl>bis-aziridine 

Downstream Products

• 1133458-63-5 3-{1-(2S,3R,4R,5S)-5-(para-toluenesulfonyl)amino-1-(para-toluenesulfonyl)-3,4-dibenzyloxy-piperidin-2-yl-methyl-1H-indol-3-yl}-4-{1-(2-[trimethylsilyl]ethoxymethyl)-1H-indol-3-yl}-1-methyl-1H-pyrrole-2,5-dione 
• 1133458-62-4 3-{1-[(2S,3R,4R,5R)-5-(para-toluenesulfonyl)aminomethyl-1-(para-toluenesulfonyl)-3,4-dibenzyloxy-pyrrolidin-2-yl-methyl]-1H-indol-3-yl}-4-{1-(2-[trimethylsilyl]ethoxymethyl)-1H-indol-3-yl}-1-methyl-1H-pyrrole-2,5-dione 

Relevant academic research and scientific papers

Synthesis of new aza-analogs of staurosporine, K-252a and rebeccamycin by nucleophilic opening of C2-symmetric bis-aziridines

Stable, water-soluble aminosugar staurosporine, K-252a and rebeccamycin analogs have been prepared by nucleophilic opening of C2-symmetric N-activated bis-aziridines by bis-indolylmaleimides. This divergent strategy allows the synthesis of unsymmetrical substituted derivatives and provides an easy access to the piperidine and pyrrolidine analogs.