171013-53-9

Upstream product

• 78-85-3 2-methylpropenal 
• 77877-20-4 (4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one 
• 158930-33-7 (4R,5S)-(CHCH₃CHPhOCONCOB(n-Bu)2CHCH₃) 

Downstream Products

• 171013-54-0 (4R,5S)-3-[(3R,4R)-3-(tert-butyldimethylsilanyloxy)-2,4-dimethylpent-4-enoyl]-4-methyl-5-phenyloxazolidin-2-one 
• 171013-69-7 (R)-4-Hydroxy-N-(3-hydroxy-5-{(Z)-4-[(4R,5S,6S)-6-(2-hydroxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-pent-3-enyl}-phenyl)-3-methoxy-N-(2,2,2-trichloro-ethoxymethyl)-butyramide 
• 180628-87-9 (R)-N-(3-Hydroxy-5-{(Z)-4-[(4R,5S,6S)-2,2,5-trimethyl-6-(2-oxo-ethyl)-[1,3]dioxan-4-yl]-pent-3-enyl}-phenyl)-3-methoxy-4-oxo-N-(2,2,2-trichloro-ethoxymethyl)-butyramide 
• 171013-67-5 (R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-[3-((Z)-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-3-methoxy-butyramide 
• 171013-68-6 C₅₆H₈₈Cl₃NO₈Si₃ 
• 186425-36-5 (2E,4E,10E)-(6R,7S,8S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-12-hydroxy-2,4,6,8,10,16-hexamethyl-14-oxo-7-triethylsilanyloxy-heptadeca-2,4,10-trienoic acid ethyl ester 
• 186425-18-3 (2E,4E,10E,12E)-(6R,7S,8S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-2,4,6,8,10,16-hexamethyl-14-oxo-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester 
• 186425-37-6 (2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester 
• 186425-19-4 (2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-hydroxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid ethyl ester 
• 186425-38-7 (2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-15-(1-ethoxy-ethoxy)-14-methoxy-2,4,6,8,10,16-hexamethyl-7-triethylsilanyloxy-heptadeca-2,4,10,12-tetraenoic acid 
• 186425-07-0 (2E,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-17-(tert-Butyl-diphenyl-silanyloxy)-7,15-dihydroxy-14-methoxy-2,4,6,8,10,16-hexamethyl-heptadeca-2,4,10,12-tetraenoic acid 
• 186425-35-4 (3R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-(1-ethoxy-ethoxy)-2,4-dimethyl-pentane-1,2-diol 
• 186425-09-2 (3R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-(1-ethoxy-ethoxy)-4-methyl-pentan-2-one 
• 186425-34-3 tert-Butyl-[(2S,3R)-3-(1-ethoxy-ethoxy)-2,4-dimethyl-pent-4-enyloxy]-diphenyl-silane 

Relevant academic research and scientific papers

Total syntheses of (+)-trienomycins A and F via a unified strategy

The first total syntheses of (+)-trienomycins A and F, representative members of a new class of cytotoxic ansamycin antibiotics, have been achieved. Key features of the unified synthetic scheme included incorporation of the (E,E,E)-triene unit with concom

Convenient syntheses of (2R,3S,4R)-3-(tert-butyldimethylsilanyloxy)-2,4-dimethyl-5-oxopentanoic acid methoxymethylamide from methacrolein. Preparation of C1-C7 and C17-C24 fragments of (+)-discodermolide

Two new highly stereoselective routes to (2R,3S,4R)-3-(tert-butyldimethylsilanyloxy)-2,4-dimethyl-5-oxopentanoic acid methoxymethylamide, an important intermediate in natural product synthesis, are described. Both schemes are considerably shorter and less

Stereocontrolled preparation of the C1-C14 polyene fragment of benzenic ansamycin antibiotics ansatrienin A and B

A practical synthesis of the C1-C14 polyene unit 5 in ansatrienin A (mycotrien l), 1a, and other ansamycin antibiotics is described which involves elaboration of the chiral unsaturated aldehyde 6 and phosphonate 7, followed by coupling of the building blocks by Horner-Emmons-olefination and Duthaler's aldolation. The synthesis of 6 successfully applies two consecutive Evans-aldol reactions for constructing the carbon backbone.

Toward the total synthesis of hygrolidin: Stereocontrolled construction of the C1-C17 seco-acid fragment and the C18-C25 masked hemiacetal subunit

Toward the first total synthesis of 16-membered macrolide antibiotic hygrolidin, the C1-C17 seco-acid fragment and the C18-C25 masked hemiacetal subunit as potential precursors have been synthesized in enantiomerically homogeneous forms. Copyright (C) 199