171016-58-3

Upstream product

• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 2612-02-4 5-methoxysalicylic acid 
• 171016-57-2 (2-Hydroxy-5-methoxy-phenyl)-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-methanone 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 171016-59-4 Toluene-4-sulfonic acid (S)-1-(5-methoxy-2-trifluoromethanesulfonyloxy-benzoyl)-pyrrolidin-2-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis of pyrrolobenzodiazepines via the PIFA oxidation of amines. Synthesis of 8-deoxy DC-81

PIFA can be used to introduce the imine moiety into a precursor to the pyrrolobenzodiazepines in 62% yield. This oxidation completes an efficient four-step synthesis of 8-deoxy DC-81.

A Direct Route to the Pyrrolobenzodiazepine Ring System Using Aryl Triflates

The pyrrolobenzodiazepine and dibenzodiazepine skeletons were rapidly generated from salicylic acids.The key step in these syntheses was the substitution of an aryl triflate.