171020-01-2

Upstream product

• 115306-75-7 3-(tertbutyldimethylsiloxyl)propylamine 
• 118786-32-6 tert-butyl 2-<(dibenzylamino)methyl>acrylate 
• 53913-96-5 tert-butyl 2-(bromomethyl)acrylate 
• 162147-07-1 N,O-bis(tert-butyldimethylsilyl)-3-amino-1-propanol 
• 103-49-1 dibenzylamine 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 171020-02-3 6-benzyl 4-tert-butyl 2-benzyl-9-(tert-butyldimethylsiloxy)-2,6-diaza-1-phenylnonane-4,6-dicarboxylate 
• 171020-04-5 6,10-dibenzyl 12-tert-butyl 14-benzyl-2,2-dimethyl-15-phenyl-5-thia-6,10,14-triaza-2-silapentadecane-6,10,12-tricarboxylate, 5,5-dioxide 
• 171020-03-4 6-benzyl 4-tert-butyl 2-benzyl-2,6-diaza-1-phenyl-9-nonanol-4,6-dicarboxylate 

Relevant academic research and scientific papers

Synthesis of a Structural Analog of Ptilomycalin A

Ptilomycalin A analog 2 was prepared by coupling amido alcohol 9 with guanidinium carboxylate 31.The synthesis of 2 requires 13 steps via a longest linear sequence from acrylate 22.

GUANIDINIUM CARBOXYLATES: PREPARATION OF 3-CARBOXYOCTAHYDRO-9aH-PYRIMIDIN-9a-YLIUM CHLORIDE

The title guanidinium carboxylate (2) was prepared from tert-butyl 2-bromomethylacrylate (3) using an 11-reaction sequence in 12percent overall yield.Sequential addition of two differentiated amino groups to the starting acrylate played a key role in the