171050-08-1Relevant articles and documents
An Alternate Enantiospecific Synthesis of Methyl (S)-7-tert-Butoxycarbonyl-2,3,4,5-Tetrahydro-4-Methyl-3-Oxo-1H-1,4-Benzodiazepine-2-Acetate
Ku, Thomas W.,Ali, Fadia E.,Bondinell, William E.,Erhard, Karl F.,Huffmann, William F.,et al.
, p. 3131 - 3134 (1997)
An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate (5) is reported.The key step, which involves an intermolecular displacement of the activated aryl fluoride (9) by L-aspartic acid β-mehtyl ester, proceeds without racemization.