171050-41-2Relevant academic research and scientific papers
Discovery of FR166124, a novel water-soluble pyrazolo[1,5-a]pyridine adenosine A1 receptor antagonist
Kuroda, Satoru,Akahane, Atsushi,Itani, Hiromichi,Nishimura, Shintaro,Durkin, Kieran,Kinoshita, Takayoshi,Tenda, Yoshiyuki,Sakane, Kazuo
, p. 1979 - 1984 (1999)
Novel 3-(2-cycloalkyl and cycloalkenyl-3-oxo-2,3-dihydropyridazin-6- yl)-2-phenylpyrazolo[1,5-a]pyridines were synthesized and evaluated for their adenosine A1 receptor binding activities. In this series, FR166124 (3) was found to be the most potent and selective adenosine A1 receptor antagonist, and the double bond of the cyclohexenyl acetic acid group was essential for selectivity of A1 receptor binding. Furthermore, the solubility in water of the sodium salt of FR166124 was high.
Pyrazolopyridine adenosine antagonists
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, (2008/06/13)
The present invention relates to a novel pyrazolopyridine compound of the following formula: STR1 wherein R1 is aryl, and R2 is cyclo(lower)alkyl which may have one or more suitable substituent(s), etc; and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said pyrazolopyridine compound or a salt thereof; a pharmaceutical composition comprising said pyrazolopyridine compound or a pharmaceutically acceptable salt thereof; etc.
