1711-94-0

Usage

General Description

1,3,4-Oxadiazol-2(3H)-one, 5-(phenylmethyl)- is a chemical compound that belongs to the oxadiazole class of compounds. It is characterized by a five-membered ring containing one oxygen atom and two nitrogen atoms. The compound contains a phenylmethyl group, which is a common functional group in organic chemistry. This chemical has potential applications in pharmaceuticals, agrochemicals, and materials science due to its unique structural properties. It may also have biological activities and medicinal properties that make it valuable for drug discovery and development. The compound is of interest to researchers and chemists for its potential uses in various industrial and scientific fields.

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 937-39-3 2-phenylacetylhydrazine 
• 99502-89-3 Chlorameisensaeure-N-hydroxy-norborn-5-en-2,3-dicarboximidester 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 23288-90-6 2-mercapto-5-benzyl-1,3,4-oxadiazole 

Downstream Products

• 130781-66-7 5-chloro-2-benzyl-1,3,4-oxadiazole 
• 137678-23-0 (5-Benzyl-2-oxo-[1,3,4]oxadiazol-3-yl)-acetic acid ethyl ester 
• 143703-81-5 5-Benzyl-3-(2-oxo-propyl)-3H-[1,3,4]oxadiazol-2-one 
• 137678-26-3 2-(5-Benzyl-2-oxo-[1,3,4]oxadiazol-3-yl)-acetamide 
• 150535-65-2 2-Benzyl-5,6-dihydro-[1,3,4]oxadiazine-4-carboxylic acid ethyl ester 
• 150535-59-4 N-(2-Oxo-3-propyl-imidazolidin-1-yl)-2-phenyl-acetamide 
• 150535-52-7 5-Benzyl-3-(2-diethylamino-ethyl)-3H-[1,3,4]oxadiazol-2-one 
• 150535-53-8 5-Benzyl-3-(2-pyrrolidin-1-yl-ethyl)-3H-[1,3,4]oxadiazol-2-one 
• 150535-54-9 5-Benzyl-3-(2-piperidin-1-yl-ethyl)-3H-[1,3,4]oxadiazol-2-one 
• 137678-28-5 N-(2,4-Dioxo-imidazolidin-1-yl)-2-phenyl-acetamide 
• 137678-43-4 N-(3-Methyl-2,4-dioxo-imidazolidin-1-yl)-2-phenyl-acetamide 
• 137678-58-1 N-(3-Amino-2,4-dioxo-imidazolidin-1-yl)-2-phenyl-acetamide 
• 137678-44-5 N-(3-Ethyl-2,4-dioxo-imidazolidin-1-yl)-2-phenyl-acetamide 
• 137678-45-6 N-(2,4-Dioxo-3-propyl-imidazolidin-1-yl)-2-phenyl-acetamide 

Relevant academic research and scientific papers

Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4- oxadiazole-2(3H)-ones in water

It has been developed for the synthesis of substituted-1,3,4-oxadiazole- 2(3H)-one derivatives via a novel one-pot, tandem procedure assisted by propylene oxide. The 5-substitued-1,3,4-oxadiazole-2(3H)-ones and 3,5-disubstitued-1,3,4-oxadiazole-2(3H)-ones were, respectively, obtained from three-component reaction of acylhydrazines, carbon disulfide, and propylene oxide, and four-component reaction of acylhydarazines, carbon disulfide, propylene oxide, and organic halides. The reactions were carried out using water as solvent in the presence of potassium phosphate to afford the expected products in good to excellent yields.

Efficient phosphonium-mediated synthesis of 2-amino-1,3,4-oxadiazoles

We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for SnAr substitution using phosphonium reagents (e.g., BOP). This approach provides convenient access to N,