171176-07-1Relevant articles and documents
Synthesis of 2′-Substituted MMI Linked Nucleosidic Dimers: An Optimization Study in Search of High Affinity Oligonucleotides for Use in Antisense Constructs
Peoc'h, Didier,Swayze, Eric E.,Bhat, Balkrishen,Sanghvi, Yogesh S.
, p. 411 - 438 (2007/10/03)
The synthesis of a series of methylene(methylimino) (MMI) linked oligodeoxyribonucleotide dimers modified at the 2′-position with fluoro and/or methoxy groups and their incorporation into different sequences has been accomplished. From these dimers, bis 2
An efficient multigram synthesis of monomers for the preparation of novel oligonucleotides containing isosteric non-phosphorous backbones
Dimock, Stuart,Bhat, Balkrishen,Peoc'h, Didier,Sanghvi, Yogesh S.,Swayze, Eric E.
, p. 1629 - 1632 (2007/10/03)
The facile preparation of two novel classes of nucleoside analogs for the inclusion as dimeric non-phosphorous containing subunits in chime fie backbones has been accomplished. The concise preparation of 3'- formylnucleosides and 5'-O-(N-methylhydroxylamino)-nucleosides is reported.