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171178-43-1

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171178-43-1 Usage

General Description

5-AMINO-2-FLUORO-ISONICOTINIC ACID is a compound with the chemical formula C6H5FNO2. It is a derivative of isonicotinic acid, a heterocyclic aromatic carboxylic acid, and contains a fluorine atom and an amino group. 5-AMINO-2-FLUORO-ISONICOTINIC ACID is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its potential for biological activity. Its unique structure and properties make it a valuable intermediate in the production of various organic compounds, and it is often utilized in the development of new drugs and other bioactive molecules. Additionally, 5-AMINO-2-FLUORO-ISONICOTINIC ACID is also utilized in the field of chemical research as a versatile tool for creating novel compounds with potential therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 171178-43-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,1,1,7 and 8 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 171178-43:
(8*1)+(7*7)+(6*1)+(5*1)+(4*7)+(3*8)+(2*4)+(1*3)=131
131 % 10 = 1
So 171178-43-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H5FN2O2/c7-5-1-3(6(10)11)4(8)2-9-5/h1-2H,8H2,(H,10,11)

171178-43-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Amino-2-fluoropyridine-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names 5-Amino-2-fluoro-isonicotinic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:171178-43-1 SDS

171178-43-1Relevant articles and documents

USE OF QUINAZOLINE-BASED TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCERS WITH NRG1 FUSIONS

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Paragraph 0049; 0054, (2021/08/06)

Provided herein are methods of selecting cancer patients for treatment with quinazoline-based tyrosine kinase inhibitors, either alone or in combination with anti- HER2/HER3 antibodies, as well as methods of treating cancer patients so selected. Cancer patients are selected for treatment if their cancer has an NRG1 fusion. Selected patients are then treated with quinazoline-based tyrosine kinase inhibitors alone or in combination with anti -HER2/HER3 antibodies.

Syntheses of [14C] and [2H4]PD0205520, an inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor

Zhang, Yinsheng,Huang, Yun,Huang, Che C.

, p. 485 - 496 (2007/10/03)

5-(4-Methyl-piperazin-1-yl)-pent-2-ynoic acid [4-(3-chloro-4-fluoro- phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-amide, PD0205520, was under investigation as a potential inhibitor of the tyrosine kinase (TK) activity of the epidermal growth factor receptor (EGFR) for cancer treatment. Both radio- and stable-isotope-labeled compounds were required for drug absorption, distribution, metabolism and excretion (ADME) and quantitative mass spectrometry bio-analytical studies. PD0205520 14C-labeled in the pyrimidine ring system was prepared in seven steps in an overall radiochemical yield of 26% from [14C]thiourea. PD0205520 2H-labeled in the piperazine ring was synthesized in four steps in a 32% overall yield. Copyright

Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

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, (2008/06/13)

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