171178-45-3

Basic information

• Product Name: 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
• Synonyms: 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE;5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOR;5-[N-(tert-Butoxycarbonyl)amino]-2-chloropyridine ,98%;(6-chloro-pyridin-3-yl)-carbamic acid, tert-butyl ester;5-tert-ButoxycarbonylaMino-2-chloropyridine;N-Boc-6-chloro-3-pyridinamine;Carbamic acid, N-(6-chloro-3-pyridinyl)-, 1,1-dimethylethyl ester
• CAS NO: 171178-45-3
• Molecular Formula: C₁₀H₁₃ClN₂O₂
• Molecular Weight: 228.68
• Product Categories: API intermediates
• Mol File: 171178-45-3.mol
• Article Data: 39

Chemical Properties

• Melting Point: 127-129°C
• Boiling Point: 283.7 °C at 760 mmHg
• Flash Point: 125.4 °C
• Appearance: /
• Density: 1.245 g/cm³
• Vapor Pressure: 0.00311mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.06±0.70(Predicted)
• CAS DataBase Reference: 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE(171178-45-3)
• EPA Substance Registry System: 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE(171178-45-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 171178-45-3(Hazardous Substances Data)

Usage

General Description

5-[N-(tert-Butoxycarbonyl)amino]-2-Chloropyridine is a chemical compound with the molecular formula C11H13ClN2O3. It is a pyridine derivative that contains a tert-butoxycarbonyl (Boc) group and a chlorine atom. 5-[N-(tert-Butoxycarbonyl)amino]-2-Chloropyridine is commonly used as a building block in organic synthesis and is often employed in the production of pharmaceuticals and agrochemicals. The Boc group serves as a protective group for the amino functionality, allowing for selective manipulation of the compound's reactivity. 5-[N-(tert-Butoxycarbonyl)amino]-2-Chloropyridine is a valuable intermediate in the synthesis of various biologically active molecules and can be utilized in the development of new drugs and crop protection agents.

InChI:InChI=1/C10H13ClN2O2/c1-10(2,3)15-9(14)13-7-4-5-8(11)12-6-7/h4-6H,1-3H3,(H,13,14)

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4548-45-2 2-chloro-5-nitropyridine 
• 1044148-99-3 3-[di(tert-butoxycarbonyl)amino]-6-chloropyridine 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 171178-46-4 5-[N-(tert-butoxycarbonyl)amino]-2-chloropyridine-4-carboxylic acid 
• 401891-55-2 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(o-tolyl)pyridin-3-yl)-N,2-dimethylpropanamide 
• 1431216-67-9 5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-2-chloro-4-(o-tolyl)pyridine 1-oxide 
• 1431216-62-4 5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-2-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridine-1-oxide 
• 1431216-60-2 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-1-oxido-4-(o-tolyl)pyridin-2-yl)-1-methylpiperazine-1-oxide 
• 1431216-61-3 1-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-4-methylpiperazine 1,4-dioxide 
• 305371-42-0 5-tert-butoxycarbonylamino-2-chloro-isonicotinic acid, methyl ester 
• 1073182-66-7 3-amino-6-chloro-2-methylisonicotinic acid 
• 1073182-63-4 3-amino-6-chloro-2-methylisonicotinic acid methyl ester 

Relevant articles and documents

Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl) piperazin-l-yl]7-(6-methoxypyridin-3-yl)-l-(2-propoxyethyl)pyrido[3,4-b] pyrazin-2(lH)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5)

We recently described a novel series of aminopyridopyrazinones as PDE5 inhibitors. Efforts toward optimization of this series culminated in the identification of 3-[4-(2-hydroxyethyl)piperazin-l-yl]7-(6-methoxypyridin-3-yl)- l-(2-propoxyethyl)pyrido[3,4-è]pyrazin-2(l//)-one, which possessed an excellent potency and selectivity profile and demonstrated robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model. Furthermore, this compound is brain penetrant and will be a useful agent for evaluating the therapeutic potential of central inhibition of PDE5. This compound has recently entered clinical trials.

Carbon-11 and Fluorine-18 Radiolabeled Pyridopyrazinone Derivatives for Positron Emission Tomography (PET) Imaging of Phosphodiesterase-5 (PDE5)

The cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) plays an important role in various pathologies including pulmonary arterial hypertension and cardiomyopathy. PDE5 represents an important therapeutic and/or prognostic targ

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.