171178-46-4

Basic information

• Product Name: 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID
• Synonyms: 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID;5-BOC-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID;4-Pyridinecarboxylic acid, 2-chloro-5-[[(1,1-dimethylethoxy)carbonyl]amino]-;5-[(tert-Butoxycarbonyl)amino]-2-chloropyridine-4-carboxylic acid;5-Amino-2-chloroisonicotinic acid, 5-BOC protected
• CAS NO: 171178-46-4
• Molecular Formula: C₁₁H₁₃ClN₂O₄
• Molecular Weight: 272.687
• Product Categories: Carboxylic Acids;Pyridines
• Mol File: 171178-46-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 420.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.390±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.52±0.36(Predicted)
• CAS DataBase Reference: 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID(171178-46-4)
• EPA Substance Registry System: 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID(171178-46-4)

Safety Data

• Statements: 20/21/22
• Safety Statements: 36/37-24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 171178-46-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

Upstream product

• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 171178-45-3 tert-butyl (6-chloropyridin-3-yl)carbamate 
• 60-29-7 diethyl ether 
• 4548-45-2 2-chloro-5-nitropyridine 
• 1072-98-6 5-chloro-2-pyridylamine 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 124-38-9 carbon dioxide 

Downstream Products

• 305371-42-0 5-tert-butoxycarbonylamino-2-chloro-isonicotinic acid, methyl ester 
• 1034131-89-9 methyl 5-(tert-butoxycarbonyl(methyl)amino)-2-chloroisonicotinate 
• 1073182-59-8 methyl 5-amino-2-chloroisonicotinate 
• 945737-64-4 2-chloro-5-(methylamino)isonicotinic acid 
• 1034131-90-2 methyl 2-chloro-5-(methylamino)isonicotinate 
• 1073182-66-7 3-amino-6-chloro-2-methylisonicotinic acid 
• 1073182-63-4 3-amino-6-chloro-2-methylisonicotinic acid methyl ester 
• 202272-71-7 (2-benzyl-1H-benzimidazol-5-yl)-(6-chloro-pyrido[3,4-d]pyrimidin-4-yl)-amine 
• 202272-68-2 GW2974 
• 202272-97-7 (1-Benzyl-1H-indol-5-yl)-(6-chloro-pyrido[3,4-d]pyrimidin-4-yl)-amine 
• 202272-67-1 (1-benzyl-1H-indazol-5-yl)-(6-chloropyrido[3,4-d]pyrimidin-4-yl)-amine 
• 189680-98-6 6-dimethylamino-3H-pyrido[3,4-d]pyrimidin-4-one 
• 189680-99-7 4-chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine 
• 171178-48-6 4,6-dichloro-pyrido<3,4-d>pyrimidine 

Relevant articles and documents

PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS

The invention relates to compounds of formula (I) or pharmaceutically acceptable salts or solvates thereof, to pharmaceutical compositions comprising them and to their use in the treatment and/or prevention of diseases or disorders mediated by histamine H4 receptor.

SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1

Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

QUINOLONES AND AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE

Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.