17119-15-2

Basic information

• Product Name: 3-HYDROXYMANDELIC ACID
• Synonyms: 3-HYDROXYMANDELIC ACID;M-HYDROXYMANDELIC ACID;3-hydroxyphenylglycolic acid;2-hydroxy-2-(3-hydroxyphenyl)acetic acid;3,α-Dihydroxybenzeneacetic acid;α,3-Dihydroxybenzeneacetic acid;alpha,3-Dihydroxybenzeneacetic acid;Einecs 241-182-3
• CAS NO: 17119-15-2
• Molecular Formula: C₈H₈O₄
• Molecular Weight: 168.15
• EINECS: 241-182-3
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Aromatics Compounds;Aromatics;C8;Carbonyl Compounds;Carboxylic Acids
• Mol File: 17119-15-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 128-132 °C
• Boiling Point: 424.3°Cat760mmHg
• Flash Point: 224.5°C
• Appearance: /
• Density: 1.48g/cm³
• Vapor Pressure: 5.91E-08mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: -20°C Freezer
• Solubility: Acetonitrile (Slightly), Methanol (Slightly)
• PKA: 3.36±0.10(Predicted)
• BRN: 2365378
• CAS DataBase Reference: 3-HYDROXYMANDELIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXYMANDELIC ACID(17119-15-2)
• EPA Substance Registry System: 3-HYDROXYMANDELIC ACID(17119-15-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 17119-15-2(Hazardous Substances Data)

Usage

Chemical Properties

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Uses

3-Hydroxymandelic Acid (cas# 17119-15-2) is a compound useful in organic synthesis.

Definition

ChEBI: A 2-hydroxy monocarboxylic acid that is mandelic acid substituted by a hydroxy group at position 3'.

General Description

3-Hydroxymandelic acid is a hydroxy acid derivative. Chiral separation of 3-hydroxymandelic acid has been achieved by ligand-exchange capillary electrochromatography.

InChI:InChI=1/C8H8O4/c9-6-3-1-2-5(4-6)7(10)8(11)12/h1-4,7,9-10H,(H,11,12)/t7-/m1/s1

Upstream product

• 53313-95-4 α,3-dihydroxybenzeneacetonitrile 
• 19473-06-4 Sodium; hydroxy-(3-hydroxy-phenyl)-methanesulfonate 
• 611-71-2 MANDELIC ACID 
• 102654-39-7 ethyl 3-hydroxymandelate 

Downstream Products

• 100-83-4 meta-hydroxybenzaldehyde 
• 53623-77-1 m-hydroxymandelic acid 
• 1360460-68-9 1-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxy-2-(3-hydroxyphenyl)ethanone 
• 152298-57-2 (3-isopropoxyphenyl)hydroxyacetic acid 
• 51777-12-9 (6R)-3-acetoxymethyl-7t-[(Ξ)-2-hydroxy-2-(3-hydroxy-phenyl)-acetylamino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; triethylamine salt 
• 99-06-9 3-Carboxyphenol 

Relevant articles and documents

Mutasynthesis of Glycopeptide Antibiotics: Variations of Vancomycin's AB-Ring Amino Acid 3,5-Dihydroxyphenylglycine

In the mutasynthetic approach, the ΔdpgA mutant of the vancomycin-type glycopeptide antibiotic producer Amycolatopsis balhimycina, which is deficient in the synthesis of 3,5-dihydroxyphenylglycine (DPg), was supplemented with synthetic DPg analogues to obtain the corresponding modified glycopeptides. Sterically more demanding 3,5-disubstituted methoxy derivatives as well as monosubstituted DPg analogues were accepted as substrates. These facts indicate that steric and electronic requirements suffice in several cases for the oxidative closure of the AB ring, thus leading to the generation of novel antibiotically active glycopeptide derivatives. The results represent a further step in evaluating the potential of mutasynthesis for peptidic secondary metabolites. Copyright

7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids

Certain 7-acylamido-3-(1-carboxy-loweralkyl-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. In a preferred embodiment the 7-substituent was 2'-aminomethylphenylacetamido.

7-(D-α-Hydroxy-2-arylacetamido)-3-(tetrazolo-[4,5-b]pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acids

7-(D-α-Hydroxy-2-arylacetamido)-3-(tetrazolo-[4,5-b]pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acids and their nontoxic, pharmaceutically acceptable salts are valuable as antibacterial agents and are particularly valuable as therapeutic agents in poultry and animals, including man, in the treatment of infectious diseases caused by many Gram-positive and Gram-negative bacteria.