17123-96-5Relevant academic research and scientific papers
Synthesis, crystal structure, deoxyribose nucleic acid interaction and antitumor activity of some thiosemicarbazonatomolybdenum(VI)
Hussein, Mouayed A.,Guan, Teoh S.,Haque, Rosenani A.,Khadeer Ahamed, Mohamed B.,Abdul Majid, Amin M.S.
, p. 270 - 283 (2014)
Four dioxomolybdenum(VI) complexes were synthesized by reacting [MoO 2(acac)2] with thiosemicarbazone ligands derived from 5-chloro-2-hydroxybenzaldehyde (H2L1), 2-hydroxy-5-methylbenzaldehyde (H2Lsu
Iron complex taking 5-chloro-2-hydroxybenzaldehyde thiosemicarbazone as ligand as well as synthesis method and application thereof
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Page/Page column 2-3, (2020/12/08)
The invention discloses an iron complex taking 5-chloro-2-hydroxybenzaldehyde thiosemicarbazone as a ligand as well as a synthesis method and application of the iron complex. The method comprises thesteps: taking 4,4-dimethyl thiosemicarbazone, 4-methyl thiosemicarbazone or thiosemicarbazone and 5-chloro-2-hydroxybenzaldehyde are respectively as raw materials to synthesize a Schiff base ligand; and reacting the synthesized ligand with ferric trichloride to obtain the iron complex. The structures of the three iron complexes synthesized by the method are brand-new structures; and experiments show that the iron complex has good anti-tumor activity on human ovarian cancer cells SKOV3, can effectively inhibit proliferation of ovarian cancer cells, is suitable for preparing drugs for treating ovarian cancer, has a more remarkable treatment effect than existing clinical drugs cis-platinum, and can prevent proliferation of cancer cells in the S phase.
