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171274-01-4

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171274-01-4 Usage

General Description

6-chloro-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-4-ol 1,1-dioxide is a chemical compound with the molecular formula C6H5ClNO3S2. It is a heterocyclic compound that contains a thieno-thiazine ring system with a chlorine substituent at the 6 position. 6-chloro-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-4-ol 1,1-dioxide is a thiazine derivative and is also known as clopamide, which is a diuretic drug used to treat high blood pressure and edema. Its chemical structure and properties make it useful for its pharmacological effects. Additionally, the molecule contains a 1,1-dioxide group, which is an important structural feature that confers certain biological activities and makes it a potential drug candidate for various therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 171274-01-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,1,2,7 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 171274-01:
(8*1)+(7*7)+(6*1)+(5*2)+(4*7)+(3*4)+(2*0)+(1*1)=114
114 % 10 = 4
So 171274-01-4 is a valid CAS Registry Number.

171274-01-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-chloro-1,1-dioxo-3,4-dihydro-2H-thieno[3,2-e]thiazin-4-ol

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:171274-01-4 SDS

171274-01-4Relevant articles and documents

Enantioselective synthesis of brinzolamide (AL-4862), a new topical carbonic anhydrase inhibitor. The "DCAT Route" to thiophenesulfonamides

Conrow, Raymond E.,Dean, W. Dennis,Zinke, Paul W.,Deason, Michael E.,Sproull, Steven J.,Dantanarayana, Anura P.,DuPriest, Mark T.

, p. 114 - 120 (2013/09/08)

A large scale synthesis of the topical carbonic anhydrase inhibitors AL-4623A (13a-HCl) and AL-4862 (13b) from 3-acetyl-2,5-dichlorothiophene ("DCAT", 1) is described. Reaction of 1 with NaSBn gave thioether 2, which was converted via sulfenyl chloride 3 and sulfenamide 5 to sulfonamide 6. Bromination of 6 gave bromo ketone 7, which upon reduction with (+)-B-chlorodiisopinocampheylborane and cyclization of the resulting bromohydrin produced S thieno[3,2-e]-1,2-thiazine 8a (96% ee) after chromatography. Treatment of 8a in THF with -BuLi at -70 °C resulted in Li-Cl exchange. Reaction of the thienyllithium with SO2 and hydroxylamine O-sulfonic acid afforded bis-sulfonamide 11a. Protection of lia as the acetimidate 12a, followed by tosylation and animation, gave R amine 13a. The synthesis of 13b proceeded via primary sulfonamide 16, which was brominated, reduced, and cyclized to give S thieno[3,2-e]-1,2-thiazine 18 (>98% ee). By virtue of the ionizable NH, 18 was separable from reduction byproducts by base extraction. Alkylation of 18 with 3-bromopropyl methyl ether afforded 8b, which was converted as above, via lib, to AL-4862 (13b). These procedures provided multihundred gram lots of 13a and 13b.

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