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1713-68-4

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1713-68-4 Usage

Type of compound

Hydrazine derivative

Usage

Organic synthesis and medicinal chemistry

Biological activity

Antifungal and antibacterial properties

Potential application

Anti-cancer agent

Structural features

a. Hydrazinecarbothioamide group
b. Dichloro-2-hydroxyphenyl group

Contribution to therapeutic potential

Structure-based activity

Versatility

Applications in medicine and research

Check Digit Verification of cas no

The CAS Registry Mumber 1713-68-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,1 and 3 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1713-68:
(6*1)+(5*7)+(4*1)+(3*3)+(2*6)+(1*8)=74
74 % 10 = 4
So 1713-68-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H11Cl2N3OS/c15-10-6-9(13(20)12(16)7-10)8-17-19-14(21)18-11-4-2-1-3-5-11/h1-8,17H,(H2,18,19,21)

1713-68-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[[(E)-(3,5-dichloro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]-3-phenylthiourea

1.2 Other means of identification

Product number -
Other names 3,5-dichloro-2-hydroxybenzaldehyde N-phenylthiosemicarbazone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1713-68-4 SDS

1713-68-4Downstream Products

1713-68-4Relevant articles and documents

In vitro biomolecular interaction studies and cytotoxic activities of copper(II) and zinc(II) complexes bearing ONS donor thiosemicarbazones

Mathews, Nimya Ann,Kurup, M.R. Prathapachandra

, (2021)

Among all the bio-metals, zinc and copper derivatives of ONS donor thiosemicarbazone have aroused great interest because of their potential biological applications. Multisubstituted thiosemicarbazone ligand H2dspt (3,5-dichlorosalicylaldehyde-N4-phenylthiosemicarbazone) derived new ternary complexes like [Zn(dspt)(phen)]?DMF (1) and [Cu(dspt)(phen)]?DMF (2), and another thiosemicarbazone, H2dsct (3,5-dichlorosalicylaldehyde-N4-cyclohexylthiosemicarbazone), derived [Cu(dsct)(bipy)]?DMF (3). These complexes have been characterized by elemental analysis (CHNS), Fourier transform infrared (FT-IR), ultraviolet–visible (UV–Vis) and proton nuclear magnetic resonance (1H-NMR) spectra. The structures of the complexes were obtained by single-crystal X-ray diffraction analysis. Compounds 1 and 2 got crystallized in the monoclinic P21/c space group. The complexes showed interesting supramolecular interaction, which in turn stabilizes the complexes. The ground state electronic configurations of the complexes were studied using the B3LYP/LANL2DZ basis set, and ESP plots of complexes were investigated. The interaction of the complexes with calf thymus DNA (CT-DNA) was studied using absorption and fluorescence spectroscopic methods. A UV study of the interaction of the complexes with calf thymus DNA (CT-DNA) has shown that the complexes can effectively bind to CT-DNA, and [Cu(dspt)(phen)]·DMF (2) exhibited the highest binding constant to CT-DNA (Kb = 3.7 × 104). Fluorescence spectral studies also indicated that Complex 2 binds relatively stronger with CT DNA through intercalative mode, exhibiting higher binding constant (Kq = 4.7 × 105). The DNA cleavage result showed that the complexes are capable of cleaving the DNA without the help of any external agent. Molecular docking studies were carried out to understand the binding of complexes with the molecular target DNA. Complex 2 exhibited the highest cytotoxicity against human breast cancer cell line MD-MBA-231 (IC50 = 23.93 μg/mL) as compared to Complex 1 (IC50 = 44.40 μg/mL).

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