1713-68-4

Basic information

• Product Name: 2-[(3,5-Dichloro-2-hydroxyphenyl)methylene]-N-phenyl-1-hydrazinecarbothioamide
• Synonyms: 1-(3,5-Dichlorosalicylidene)-4-phenylthiosemicarbazide;2-[(3,5-Dichloro-2-hydroxyphenyl)methylene]-N-phenyl-1-hydrazinecarbothioamide;3,5-Dichlorosalicylaldehyde 4-phenyl thiosemicarbazone;(2E)-2-(3,5-dichloro-2-hydroxybenzylidene)-N-phenylhydrazinecarbothioamide
• CAS NO: 1713-68-4
• Molecular Formula: C14H11 Cl2 N3 O S
• Molecular Weight: 340.2276
• Mol File: 1713-68-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 403.1°Cat760mmHg
• Flash Point: 197.6°C
• Appearance: /
• Density: 1.47g/cm³
• Vapor Pressure: 1.05E-06mmHg at 25°C
• Refractive Index: 1.696
• PKA: 6.02±0.50(Predicted)
• CAS DataBase Reference: 2-[(3,5-Dichloro-2-hydroxyphenyl)methylene]-N-phenyl-1-hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(3,5-Dichloro-2-hydroxyphenyl)methylene]-N-phenyl-1-hydrazinecarbothioamide(1713-68-4)
• EPA Substance Registry System: 2-[(3,5-Dichloro-2-hydroxyphenyl)methylene]-N-phenyl-1-hydrazinecarbothioamide(1713-68-4)

Safety Data

• Hazardous Substances Data: 1713-68-4(Hazardous Substances Data)

Usage

Type of compound

Hydrazine derivative

Usage

Organic synthesis and medicinal chemistry

Biological activity

Antifungal and antibacterial properties

Potential application

Anti-cancer agent

Structural features

a. Hydrazinecarbothioamide group
b. Dichloro-2-hydroxyphenyl group

Contribution to therapeutic potential

Structure-based activity

Versatility

Applications in medicine and research

InChI:InChI=1/C14H11Cl2N3OS/c15-10-6-9(13(20)12(16)7-10)8-17-19-14(21)18-11-4-2-1-3-5-11/h1-8,17H,(H2,18,19,21)

Upstream product

• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 90-60-8 3,5-dichlorosalicyclaldehyde 
• 103-72-0 phenyl isothiocyanate 

Relevant articles and documents

In vitro biomolecular interaction studies and cytotoxic activities of copper(II) and zinc(II) complexes bearing ONS donor thiosemicarbazones

Among all the bio-metals, zinc and copper derivatives of ONS donor thiosemicarbazone have aroused great interest because of their potential biological applications. Multisubstituted thiosemicarbazone ligand H2dspt (3,5-dichlorosalicylaldehyde-N4-phenylthiosemicarbazone) derived new ternary complexes like [Zn(dspt)(phen)]?DMF (1) and [Cu(dspt)(phen)]?DMF (2), and another thiosemicarbazone, H2dsct (3,5-dichlorosalicylaldehyde-N4-cyclohexylthiosemicarbazone), derived [Cu(dsct)(bipy)]?DMF (3). These complexes have been characterized by elemental analysis (CHNS), Fourier transform infrared (FT-IR), ultraviolet–visible (UV–Vis) and proton nuclear magnetic resonance (1H-NMR) spectra. The structures of the complexes were obtained by single-crystal X-ray diffraction analysis. Compounds 1 and 2 got crystallized in the monoclinic P21/c space group. The complexes showed interesting supramolecular interaction, which in turn stabilizes the complexes. The ground state electronic configurations of the complexes were studied using the B3LYP/LANL2DZ basis set, and ESP plots of complexes were investigated. The interaction of the complexes with calf thymus DNA (CT-DNA) was studied using absorption and fluorescence spectroscopic methods. A UV study of the interaction of the complexes with calf thymus DNA (CT-DNA) has shown that the complexes can effectively bind to CT-DNA, and [Cu(dspt)(phen)]·DMF (2) exhibited the highest binding constant to CT-DNA (Kb = 3.7 × 104). Fluorescence spectral studies also indicated that Complex 2 binds relatively stronger with CT DNA through intercalative mode, exhibiting higher binding constant (Kq = 4.7 × 105). The DNA cleavage result showed that the complexes are capable of cleaving the DNA without the help of any external agent. Molecular docking studies were carried out to understand the binding of complexes with the molecular target DNA. Complex 2 exhibited the highest cytotoxicity against human breast cancer cell line MD-MBA-231 (IC50 = 23.93 μg/mL) as compared to Complex 1 (IC50 = 44.40 μg/mL).