171336-72-4

Basic information

• Product Name: (2R,4R)-1-benzyl-2-ethoxycarbonylpyrrolidine-4-spiro-5'-hydantoin
• Synonyms: (2R,4R)-1-benzyl-2-ethoxycarbonylpyrrolidine-4-spiro-5'-hydantoin
• CAS NO: 171336-72-4
• Molecular Weight: 317.345
• Mol File: 171336-72-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,4R)-1-benzyl-2-ethoxycarbonylpyrrolidine-4-spiro-5'-hydantoin(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-1-benzyl-2-ethoxycarbonylpyrrolidine-4-spiro-5'-hydantoin(171336-72-4)
• EPA Substance Registry System: (2R,4R)-1-benzyl-2-ethoxycarbonylpyrrolidine-4-spiro-5'-hydantoin(171336-72-4)

Safety Data

• Hazardous Substances Data: 171336-72-4(Hazardous Substances Data)

Upstream product

• 77449-94-6 (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride 
• 151-50-8 potassium cyanide 
• 506-87-6 ammonium carbonate 
• 171192-74-8 (2R)-ethyl N¹-benzyl-4-oxopyrrolidine-2-carboxylate 

Downstream Products

• 188966-66-7 (2R,4R)-4-Benzoylamino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester 
• 188966-65-6 (2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester 
• 188966-64-5 (2R,4R)-4-Amino-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester 
• 171336-79-1 (2S,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid 
• 169209-63-6 (2R,4R)-4-amino-4-carboxyproline 
• 171336-76-8 (2R,4R) 4-amino-1-(benzyl)-pyrrolidine-2,4-dicarboxylic acid 

Relevant articles and documents

Asymmetric syntheses of all four isomers of 4-amino-4-carboxyproline: Novel conformationally restricted glutamic acid analogues

Asymmetric syntheses of all four isomers of 4-amino-4-carboxyprolines, i.e. (2S,4S)-3, (2S,4R)-4, and their corresponding enantiomers, as novel conformationally restricted analogues of glutamic acid, were performed from trans-4-hydroxy-L-proline as a homochiral starting material. The key step was the spirohydantoin ring formation by employing the Bucherer-Bergs reaction of 4-oxoproline derivatives. These structures were determined by NMR studies.