171367-22-9

Basic information

• Product Name: Metoclopramide N-Oxide
• Synonyms: Metoclopramide N-Oxide;4-AMino-5-chloro-N-[2-(diethylaMino)ethyl]-2-MethoxybenzaMide N-Oxide;4-AMino-5-chloro-N-[2-(diethyloxidoaMino)ethyl]-2-MethoxybenzaMide;MetoclopraMide N-Oxide (IMpurity G);Metoclopramide EP Impurity G;Metoclopramide BP Impurity G
• CAS NO: 171367-22-9
• Molecular Formula: C₁₄H₂₂ClN₃O₃
• Molecular Weight: 315.79578
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Nitric Oxide Reagents;Pharmaceuticals
• Mol File: 171367-22-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
• PKA: 12.96±0.46(Predicted)
• Stability: Hygroscopic, Temperature Sensitive
• CAS DataBase Reference: Metoclopramide N-Oxide(CAS DataBase Reference)
• NIST Chemistry Reference: Metoclopramide N-Oxide(171367-22-9)
• EPA Substance Registry System: Metoclopramide N-Oxide(171367-22-9)

Safety Data

• Hazardous Substances Data: 171367-22-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 171367-22-9 differently. You can refer to the following data:
1. A new metabolite of Metoclopramide (M338685).
2. Metoclopramide N-Oxide (Metoclopramide EP Impurity G) is a new metabolite of Metoclopramide (M338685).

Upstream product

• 364-62-5 metoclopramide 
• 820965-31-9 5-Chloro-N-(2-diethylamino-ethyl)-2-methoxy-4-(2,2,2-trifluoro-acetylamino)-benzamide 

Downstream Products

• 27260-19-1 N-deethyl-Metoclopramide 

Relevant articles and documents

Identification and full characterization of a new metabolite of metoclopramide

The metabolism of metoclopramide 1 has been reinvestigated by HPLC coupled with mass spectrometry.The urine of healthy volunteers showed the presence of a new metabolite 2 derived from the enzymatic oxidation of the primary aromatic amino group of 1 to the hydroxylamino moiety.The structure of the new metabolite was ascertained by its fragmentation pattern in the mass spectrometer and unambiguously secured by an independent synthesis.In addition, the tertiary amine group of 1 was selectively oxidized to the corresponding N-oxide.This compound and its ring oxidation metabolites were not detected in the urine of the tested volunteers. metoclopramide metabolism / metabolite / arylhydroxylamino derivative / metoclopramide N-oxide