1715-30-6

Usage

Uses

1. Used in Dental Applications:
N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride is used as an antibacterial and antiplaque agent for its effectiveness against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii, which are common bacteria associated with dental plaque and gum disease.
2. Used in Antimicrobial Research:
N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride is used as an antiseptic to study its antimicrobial activity in saliva-derived microcosm biofilms, which can help in understanding its potential applications in controlling oral infections and maintaining oral hygiene.
3. Used in Immunological Research:
N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride is used as a protein tyrosine phosphatase localized to the mitochondrion 1 (PTPMT1)-specific inhibitor to study its effects on the spare respiratory capacity and viability of CD8+ T cells, which are crucial components of the immune system.
4. Used in Antiviral Research:
N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride is used as a PTPMT1 inhibitor to study its antiviral effect on human cytomegalovirus (HCMV) replication in HCMV-infected human foreskin fibroblast (HFF) cells, which can provide insights into the development of new antiviral therapies.

Biological Activity

selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (ptpmt1) (ic50 = 1.08 μm in vitro). stimulates increased insulin secretion by β-cells in rat pancreatic islets. displays antitcancer properties in fadu cells.

Biochem/physiol Actions

Alexidine dihydrochloride is a bisbiguanide compound. It has been studied in the treatment of head and neck cancer. Alexidine dihydrochloride also exhibits antibiofilm and antifungal activity against several fungal species. It causes mitochondrial apoptosis in mammalian cells due to its anti-cancer activity. Alexidine dihydrochloride is a component of oral disinfectant and contact lens solution.