171503-15-4Relevant articles and documents
SYNTHESIS AND ANTITUMOR ACTIVITY OF NOVEL &α-SUBSTITUTED AMINOMETHYLPHOSPHONATES
Chen, Ru-Yu,Mao, Li-Juan
, p. 97 - 104 (2007/10/02)
Two series of novel α-substituted aminomethyl phosphonates (1) and (2) have been synthesized and the reaction conditions are discussed.All the products have been confirmed by 1H NMR, IR spectra and elemental analysis, and x-ray diffraction.The bioassay showed that some of the compounds inhibit the growth of the leukemia L1210 cell in vitro.Key words: Aminomethylphosphonate; synthesis; antitumor activity; X-ray diffraction.