171503-19-8

Upstream product

• 1809-20-7 diisopropyl hydrogenphosphonate 
• 130517-96-3 N-(4-chlorobenzylidene)benzylamine 
• 104-88-1 4-chlorobenzaldehyde 
• 100-46-9 benzylamine 

Downstream Products

• 171503-06-3 (C₆H₅)3GeCH₂CH₂C(O)N(CH₂C₆H₅)(CHC₆H₄Cl)(P(O)(OCH(CH₃)2)2) 

Relevant academic research and scientific papers

Copper (i) iodide-catalyzed solvent-free synthesis of α- aminophosphonates

A method for the synthesis of α-aminophosphonates through the three-component coupling reaction of aldehydes, amines, and diisopropyl phosphite using copper (I) iodide salt catalyst is demonstrated, The reaction is highly efficient, economic, and also env

SYNTHESIS AND ANTITUMOR ACTIVITY OF NOVEL &α-SUBSTITUTED AMINOMETHYLPHOSPHONATES

Two series of novel α-substituted aminomethyl phosphonates (1) and (2) have been synthesized and the reaction conditions are discussed.All the products have been confirmed by 1H NMR, IR spectra and elemental analysis, and x-ray diffraction.The bioassay showed that some of the compounds inhibit the growth of the leukemia L1210 cell in vitro.Key words: Aminomethylphosphonate; synthesis; antitumor activity; X-ray diffraction.