17153-01-4

Upstream product

• 51127-13-0 2-phenyl-4-methyl-4H-oxazolin-5-one 
• 79-22-1 methyl chloroformate 

Downstream Products

• 22260-84-0 4-(4-methyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-4H-pyridine-1-carboxylic acid methyl ester 
• 22260-92-0 4-tert-butyl-2-(4-methyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2H-pyridine-1-carboxylic acid methyl ester 
• 17136-90-2 benzoylamino-methyl-malonic acid monomethyl ester 

Relevant academic research and scientific papers

Kinetic resolution displaying zeroth order dependence on substrate consumption: Copper-catalyzed asymmetric alcoholysis of azlactones

Kinetic resolution of 4-alkyl-2-aryl-5-oxo-4,5-dihydrooxazole-4-carboxylic acid esters (azlactones 1) were achieved by copper-DTBM-SEGPHOS catalyzed alcoholysis reaction with good selectivity (12 examples). Variation of ee of unreacted substrates 1 and pr